重庆医学2016，Vol.45Issue(33)：4619-4621,3.DOI:10.3969/j.issn.1671-8348.2016.33.004
卵巢癌不易发生脑转移的机制探讨
Investigation on mechanism of ovarian cancer scarcely developing brain metastasis
摘要
Abstract
Objective To observe the intracranial tumorigenicity situation of lung cancer cell strain and ovarian cell strain by injecting them into the female nude mice with different approaches and to analyze the possible mechanism for scarce brain metastasis of ovarian cancer to provide a certain thinking for the treatment of brain metastasis of lung cancer.Methods Ovarian cancer cell strain Skov3 and lung cancer cell strain A549 were injected into female nude mice respectively through tail veins,abdominal cavity,common carotid artery and brain tissue.There were 16 nude mice in each approach.All the nude mice were killed 4-6 weeks later.Then the brain,lungs,kidneys,spleen,liver,fallopian tube,ovary and abdominal tumor mass were taken by HE staining for observing the cerebral tumorigenicity situation.Results By the caudal vein injection,there was no brain metastasis in the Skov3 strain group,while in the A549 strain group,2 cases of brain metastasis occurred.By the aabdominal cavity injection,there was no brain metastasis in the Skov3 strain group,but 2 cases of brain metastasis occurred in the A549 strain group.By the common ca rotid artery injection,there was no brain metastasis in the Skov3 strain group,but 8 cases of brain metastases occurred in the A549 group.The intracranial tumorigenicity of Skov3 strain and A549 strain had statistical difference among these 3 kinds of extracranial injection approaches(P＜0.01).By intracranial direct injection approach,14 cases of brain tumorigenicity occurred in the Skov3 strain group,while 10 cases of brain tumorigenicity occurred in the A549 strain group,the difference had no statistical difference.Conclusion Blood brain barrier maybe plays an important role in preventing ovarian cancer cells from metastasizing into brain.关键词
卵巢肿瘤/肺肿瘤/脑转移/裸鼠/血脑屏障Key words
ovarian neoplasms/lung neoplasms/brain metastasis/nude mice/blood brain barrier分类
医药卫生引用本文复制引用
杜琴,郑艺,雷开键,贾钰铭..卵巢癌不易发生脑转移的机制探讨[J].重庆医学,2016,45(33):4619-4621,3.基金项目
四川省卫生厅科技基金资助项目(120014) （120014）
四川省宜宾市科技基金资助项目(2012ZSF007). （2012ZSF007）
