重庆医学2016，Vol.45Issue(33)：4622-4624,4628,4.DOI:10.3969/j.issn.1671-8348.2016.33.005
谷氨酰胺对克雷伯杆菌引起的大鼠肺炎炎症的抑制作用
Inhibition of glutamine on inflammation of rats with pneumonia induced by Klebsiella pneumonia
禹刚 1简丽萍2
作者信息
- 1. 四川省阿坝州人民医院重症科,四川马尔康624000
- 2. 西南医科大学,四川泸州646000
- 折叠
摘要
Abstract
Objective To explore the inhibition effect of glutamine on the inflammation of rats with pneumonia induced by Klebsiella pneumoniae.Methods Thirty-six SD rats were randomly divided into the normal group,model group and glutamine treatment group.The rat pneumonia model was established by intratracheal instillation of Klebsiella Bacillus pneumonia.Results Compared with the model group,the glutamine treatmernt group could reduce the ratio of W/D(5.98±0.29)vs.(4.32±0.33)(P＜ 0.05),alleviated the lung tissue edema,inflammatory cell infiltration and then improved the morphology of the lung tissue,inhibited the IL-6,IL-1 and TNF-α secretion in serum and lung homogenate(P＜0.05),and inhibited the level of NF-κB p65 and IκBα phosphorylation.Conclusion Glutamine inhibits the inflammation of rats with pneumonia induced by Klebsiella pneumoniae,which might be related to NF-κB signal pathway.关键词
谷氨酰胺/克雷伯菌,肺炎/肺炎/炎症/NF-κB信号通路Key words
glutamine/Klebsiella pneumonia/pneumoniae/inflammation/NF-κB signal pathway分类
医药卫生引用本文复制引用
禹刚,简丽萍..谷氨酰胺对克雷伯杆菌引起的大鼠肺炎炎症的抑制作用[J].重庆医学,2016,45(33):4622-4624,4628,4.
