重庆医学2016，Vol.45Issue(33)：4650-4652,3.DOI:10.3969/j.issn.1671-8348.2016.33.013
SNCA基因多态性与帕金森病认知障碍的相关性分析
Analysis on correlation between SNCA gene polymorphism and cognitive disorders of Parkinson's disease
摘要
Abstract
Objective To study a-synuclein(SNCA)rs356200 and rs356165 loci polymorphism in the patients with Parkin son's disease(PD)and to investigate the correlation between SNCA gene polymorphism and PD cognitive impairment.Methods One hundred and twenty cases of PD in our hospital from June 2014 to December 2015 and 120 heaalthy people were selected as the research subjects.The PD cases served as the PD group and 120 healthy subjects as control group.The PD cases were also divided into the cognitive impairment group and non-cognitive impairment group according to the cognitive impairment.The rs356200 and rs356165 allele frequencies and genotype in each group were studied.Results The rs356200 allele frequency had statistical difference between the PD group and control group(P＜0.05),the rs356200 G/G,A/A and A/G genotype had statistical difference between the PD group and control group(P＜0.05).The rs356165 allele frequency had no statistical difference between the PD group and the control group(P＞0.05),the rs356165 G/G,A/A and A/G genotype had statistical difference between the PD group and control group(P＜0.05).The rs356200 and rs356165 allele frequencies and genotype had no statistical difference between the cognitive impairmentgroup and non-cognitive impairment group(P＞0.05).Conclusion The morbidity of PD is related to SNCA gene rs356200 and rs356165 sites polymorphism.PD cognitive dysfunction has no significant correlation with SNCA gene rs356200 and rs356165 loci polymorphism.关键词
α-突触核蛋白/基因多态性/帕金森病/认知功能障碍Key words
α-s ynuclein gene polymorphism/Parkinson's disease/cognitive dysfunction分类
医药卫生引用本文复制引用
宋天琦,白洋,闫旭..SNCA基因多态性与帕金森病认知障碍的相关性分析[J].重庆医学,2016,45(33):4650-4652,3.基金项目
吉林省科技发展计划项目(20130522018JH). （20130522018JH）
