重庆医学2017，Vol.46Issue(10)：1346-1348,3.DOI:10.3969/j.issn.1671-8348.2017.10.015
血清PG、G-17联合CA72-4和13C UBT在早期胃癌的诊断价值
Diagnostic value of serum PG,G-17 combined with CA72-4 and 13C UBT in early gastric cancer
摘要
Abstract
Objective To investigate the change situation of serum pepsinogen (PG) and gastrin-17(G-17) levels change in gastric cancer,and on this basis diagnostic significance of combined detection of carbohydrate antigen 72-4 (CA72-4) and 13C urea breath test (13C UBT) detection in early gastric cancer.Methods The enzyme-linked immunosorbent (ELISA) method was used to detect serum PG Ⅰ,PG Ⅱ and G-17 levels in healthy people,atrophic gastritis group and gastric cancer group.Firstly the changes of above three indicators were compared;then according to PG Ⅰ and G-17,the carcinoma group was divided into the group A,B,C and D,these four groups were detected the helicobacter pylori infection status by 13C UBT.Finally the CA72-4 levels were performed the statistics by using the tumor markers detection results.Results Serum PG Ⅰ level and PG Ⅰ/PG Ⅱ ratio in the control group,atrophic gastritis group and gastric cancer group was gradually declined,the difference was statistically significant (P＜0.05);serum G-17 level in the control group,atrophic gastritis group and gastric cancer group was gradually increased,the difference among 3 groups was statistically significant (P＜0.05);in early gastric cancer rate ratio among 4 groups,which in the group B was highest,the difference was statistically significant (P＜0.05);in the comparison of positive rates of 13 C UBT and CA72-4 level in early gastric cancer among 4 group,the 13 C UBT positive rate and CA72-4 level in the group B were higher than those in the group A,C and D,the differences were statistically significant (P＜0.05).Moreover the CA72-4 level in the group B had significant difference between early gastric cancer and advanced gastric cancer (P＜0.01).Conclusion Serum PG Ⅰ reduce and G-17 increase combined with CA72-4 high level and 13C UBT positive have an important forewarning value for the diagnosis of gastric cancer.关键词
胃蛋白酶原/胃泌素17/螺杆菌,幽门/CA72-4/胃肿瘤Key words
gastrin/pepsinogen 17/helicobacter pylori/CA72-4/gastric neoplasms分类
医药卫生引用本文复制引用
黄喜顺,邓立新,邱耀辉,苏军凯..血清PG、G-17联合CA72-4和13C UBT在早期胃癌的诊断价值[J].重庆医学,2017,46(10):1346-1348,3.基金项目
福建省自然科学基金资助项目(2013J01394). （2013J01394）
