动物营养学报2016，Vol.28Issue(6)：1661-1669,9.DOI:10.3969/j.issn.1006-267x.2016.06.005
印记基因对哺乳动物胚胎和胎盘发育的调控机制
Imprinted Genes: Regulatory Mechanism on Development of Mammalian Embryos and Placenta
摘要
Abstract
Imprinted genes play a significant role in the regulation of life processes in mammals.In the early stage of life,imprinted genes adjust allele's expression or silence with epigenetic modification and subsequently regulate the growth of embryos and placenta.The abnormal expressions of imprinted genes are closely related to fetal growth restriction,developmental arrest and thyroid detoxification in the embryos and placenta,so it is important to explore the regulation mechanisms of imprinted genes on the development of embryos and placenta for the purpose of prevention from intrauterine growth restriction,congenitial defect and potential diseases late in the life.This review summarized the main characteristics of imprinted genes,erasure and reconstruction of the imprinting of the sex gonad and the related epigenetic modification,and the latest research progress in the development of mammalian embryos and placenta affected by imprinted genes.关键词
印记基因/哺乳动物/胚胎/胎盘/表观遗传修饰Key words
imprinted gene/mammalian/embryo/placenta/epigenetic modification分类
农业科技引用本文复制引用
徐涓之,颜琼娴,伍小松,谭支良..印记基因对哺乳动物胚胎和胎盘发育的调控机制[J].动物营养学报,2016,28(6):1661-1669,9.基金项目
湖南省自然科学基金项目(13JJ6102) （13JJ6102）
中国科学院外籍青年科学家计划(2013Y2GA0010) （2013Y2GA0010）
