南方医科大学学报2017，Vol.37Issue(4)：444-450,7.DOI:10.3969/j.issn.1673-4254.2017.04.04
上皮性卵巢癌中八聚体结合转录因子4、Notch1及DLL4的表达及其临床意义
Expressions of OCT4, Notch1 and DLL4 and their clinical implications in epithelial ovarian cancer
摘要
Abstract
Objective To investigate the correlations among OCT4, Notch1 and DLL4 and their association with the clinicopathological features of patients with epithelial ovarian cancer (EOC). Methods A total of 207 specimens of EOC and 65 specimens of benign ovarian epithelial tumor tissues were examined for expressions of OCT4, Notch1 and DLL4 proteins using immunohistochemistry. Results The positivity rates of OCT4, Notch1 and DLL4 in EOC tissues were 60.0%, 61.8%and 60.9%, respectively, significantly higher than the rates in benign epithelial tumor tissues (9.2%, 6.2%, and 0, respectively; P<0.05). The expressions of OCT4, Notch1 and DLL4 in EOC were significantly correlated with tumor differentiation, FIGO stage, and lymph node metastasis (P<0.05). DLL4 was positively correlated with OCT4 and Notch1 expressions (r=0.758 and 0.704, respectively, P<0.001), and the latter two were also positively correlated (r=0.645, P<0.001). Overexpressions of OCT4, Notch1 and DLL4 were associated with a poor prognosis, and the survival rate was significantly lower in patients positive for OCT4, Notch1, and DLL4 than in the negative patients (P<0.05). FIGO stage and expressions of OCT4 and DLL4 were independent prognostic factors of EOC (P<0.05). Conclusion The expressions of OCT4, Notch1 and DLL4 are correlated with the differentiation, lymph node metastasis, clinical stage and prognosis of EOC. Combined detection of the 3 proteins has an important value in predicting the progression and prognosis of EOC.关键词
上皮性卵巢癌/八聚体结合转录因子4/Notch1/DLL4/预后Key words
epithelial ovarian cancer/OCT4/Notch1/DLL4/prognosis引用本文复制引用
俞岚,焦云杰,周蕾,宋文庆,武世伍,王丹娜..上皮性卵巢癌中八聚体结合转录因子4、Notch1及DLL4的表达及其临床意义[J].南方医科大学学报,2017,37(4):444-450,7.基金项目
安徽省高校自然科学研究重点项目(KJ2017A224) （KJ2017A224）
安徽省高等学校省级优秀青年人才基金项目(2012SQRL094) （2012SQRL094）
蚌埠医学院自然科学类重点项目(BYKY1416ZD) （BYKY1416ZD）
国家级大学生创新训练项目(201610367015) （201610367015）
