南方医科大学学报2017，Vol.37Issue(4)：470-474,5.DOI:10.3969/j.issn.1673-4254.2017.04.08
投影数据恢复方法在低剂量脑灌注CT成像中的应用
Sinogram restoration for low-dose cerebral perfusion CT images
摘要
Abstract
Objective In clinical cerebral perfusion CT examination, repeated scanning the region of interest in the cine mode increases the radiation dose of the patients, while decreasing the radiation dose by lowering the scanning current results in poor image quality and affects the clinical diagnosis. We propose a penalized weighted least-square (PWLS) method for recovering the projection data to improve the quality of low-dose cerebral perfusion CT imaged. This method incorporates the statistical distribution characteristics of brain perfusion CT projection data and uses the statistical properties of the projection data for modeling. The PWLS method was used to recover the data, and the Gauss-Seidel (GS) method was employed for iterative solving. Adaptive weighting is introduced between the original projection data and the projection data after PWLS restoration. The experimental results on the clinical data demonstrated that the PWLS-based sinogram restoration method improved noise reduction and artifact suppression as compared with the conventional noise reduction methods, and better retained the edges and details to generate better cerebral perfusion maps.关键词
低剂量/脑灌注CT/投影数据恢复/惩罚加权最小二乘Key words
low-dose/cerebral perfusion computed tomography/sinogram restoration/penalized weighted least-square引用本文复制引用
田秀梅,黄静,林嘉慧,张忻宇,马建华,边兆英..投影数据恢复方法在低剂量脑灌注CT成像中的应用[J].南方医科大学学报,2017,37(4):470-474,5.基金项目
国家自然科学基金(81371544,61571214) （81371544,61571214）
广东省自然科学基金(2015A030313271) Supported by National Natural Science Foundation of China (81371544, 61571214). （2015A030313271）
