南方医科大学学报2017，Vol.37Issue(4)：542-545,550,5.DOI:10.3969/j.issn.1673-4254.2017.04.21
阿尔茨海默病患者血清脂联素水平与认知功能的相关性
Correlation between serum adiponectin level and cognitive function in patients with Alzheimer's disease
摘要
Abstract
Objective To investigate serum adiponectin level in patients with Alzheimer's disease (AD) and its correlation with the patients' cognitive function. Methods This case-control study was conducted in 90 patients with a highly probable diagnosis ofAD, who were divided into mild, moderate and severe group saccording to the MMSE score. Ninety healthy subjects matched for age and gender with the AD patients were selected as the control group. The serum levels ofadiponectin in the participants were detected using enzyme-linked immunosorbent assay. Results Serum adiponectin level was significantly lower in the AD group than in the control group (P<0.05). Of the 3 subgroups of the AD patients, the moderate and severe AD groups showed significantly lower serum adiponectin level sthan the control group (P<0.05), but the difference in adiponectin levels was not significant between the mild AD group and the control group (P>0.05);serum adiponectin levels also differed significantly among the 3 subgroups of AD patients (P<0.05). Serum adiponectin level was positively correlated with the MMSE score in the AD patients (r=0.683, P<0.001). Conclusion Serum adiponectin levels are reduced in AD patients and associated with the degree of cognitive impairment.关键词
阿尔茨海默病/脂联素/认知功能Key words
Alzheimer's disease/adiponectin/cognitive function引用本文复制引用
李维,田怡,邓炎尧,奉夏露,王艳,冯辉,侯德仁..阿尔茨海默病患者血清脂联素水平与认知功能的相关性[J].南方医科大学学报,2017,37(4):542-545,550,5.基金项目
湖南省科技厅重点研发计划(2015SF2029-2,2016JC2052) （2015SF2029-2,2016JC2052）
长沙市第一医院院级课题(Y2016-05) （Y2016-05）
中南大学湘雅三医院新湘雅人才工程"至善领跑计划"(20150305) （20150305）
