摘要
Abstract
Objective:To explore the clinical features of male children with systemic lupus erythematosus (SLE).Methods:Forty one male and 204 female children with SLE were admitted from our hospital during January 2006 to August 2015.Forty one females were extracted from the 204 females to compare with 41 males.Results:No statistical differences were found in the age of onset,native place,family history of rheumatic disease,clinical initial manifestations,inflammatory indexs and immunological indexs between two groups (P＞0.05).The clinical initial manifestations were fever,rash,edema,pain in joints and muscles in both two groups.There were significant differences in positive incidence of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (P＜0.05) in intra-group comparison.No statistical differences were found in the incidence of proteinuria,renal insufficiency,blood system damage,cardiac damage and neuropsychiatric systemic lupus erythematosus (NPSLE) between the two groups (P＞0.05).Type Ⅳ was the most common pathology classification of 28 male and 20 female children with renal biopsy.Glucocorticoids and immunosuppressants were the main medicines for treatment.Evaluated the outcomes by systemic lupus erythematosus disease activity index (SLEDAI) score system,the improvement rate of two groups were 87.8％ (36 cases) in male group and 82.9％ (34 cases) in female group (P＞0.05).The mortality of two groups were 4.9％ (2 cases of male) and 12.2％ (5 cases of female) (P＞0.05).Average onset age of the 7 dead cases was (8.0±1.9) years old,which was younger than the average onset age (11.2±2.5) years old of total 82 cases (P＜0.05).Conclusion:Male SLE children usually take fever,rash,edema,joints and muscles pain as the major initial manifestations.Urinary system,blood system,cardiac system and neuropsychopathic system are easily involved.Type Ⅳ is the most common pathology classification in the male children with lupus nephritis.The younger onset age might indicate a worse prognosis.关键词
系统性红斑狼疮/男性/儿童/临床分析Key words
systemic lupus erythematosus/male/chidren/clinical analysis分类
医药卫生
