国际医学放射学杂志2017，Vol.40Issue(2)：119-123,5.DOI:10.19300/j.2017.L4264
双低剂量CTA评估颅内动脉粥样斑块稳定性的可行性研究
Stability of intracranial artery atheromatous plaque:evalution using double low doses CTA
摘要
Abstract
Objective To explore the feasibility of dual low-dose CT angiography (CTA) to assess plaque stability. Methods Forty-two cases (male n=29, female n=13;age 62.3±7.69 years) who suffered from cerebral ischemic stroke in our Department of Neurology during January 2015 to March 2016 were recruited. They were randomly divided into two groups, dual low-dose group and the conventional dose group, 21 cases in each group. Each group of patients received CTA with tube voltage and iodinated contrast agent dose 80 kV and 50 mL in dual low-dose group, and 120 kV and 100 mL in conventional dose group. Post processing of intracranial arterial plaque was conducted. The t-test was used to compare the image quality, degree of vascular enhancement, and X-ray radiation dose between the two groups. Chi-square test was used to compare the difference in plaque detection rate between the two groups. Results The standard deviation was significantly higher in dual low-dose group than in the conventional dose group (P<0.05). The contrast noise ratio and signal noise ratio did not significantly differ between the two groups(P>0.05). The dual low-dose group had higher CT values at middle cerebral artery M1 segment and vertebral basilar artery than that of conventional tube voltage group (all P<0.05). The image quality showed good in both groups (>2 points) and did not significantly differ from each other (P>0.05). The plaque detection rates had no statistical significance between the two groups (P>0.05). The CT dose index volume, dose length product, and effective dose in the dual low-dose group were lower than in the conventional dose group (all P<0.05). Conclusions CTA with dual low-dose technique can clearly demonstrate morphology and composition of intracranial arterial plaque, can lead to relatively accurate judgments on plaque stability, and can effectively reduce doses of ionizing radiation and nephrotoxic iodine contrast agent. Therefore, dual low-dose CTA assessment of intracranial arterial plaque stability is feasible and worthy of promotion and has clinical application value.关键词
缺血性脑卒中/粥样斑块/体层摄影术,X线计算机/血管造影/辐射剂量/对比剂Key words
Cerebral ischemic stroke/Athermanous plaque/Tomography,X-ray computer/Angiography/Radiation dose/Contrast agent分类
医药卫生引用本文复制引用
李丰章,胡含明,巫启恒,邹南安,丁绍纯,刘霞,熊建忠..双低剂量CTA评估颅内动脉粥样斑块稳定性的可行性研究[J].国际医学放射学杂志,2017,40(2):119-123,5.基金项目
萍乡市指导性科技计划项目(2015N016) （2015N016）
