国际病理科学与临床杂志2017，Vol.37Issue(1)：50-55,6.DOI:10.3978/j.issn.2095-6959.2017.01.010
成骨细胞特异性转录因子2在乳腺癌中的表达及临床意义
Expression and clinical significance of runt-related transcription factor 2 in breast carcinoma
周炳娟 1黄丽娟 2曹建江 2马小乐 2孙吉瑞 2乔海芝 1赵文明 1张金库1
作者信息
- 1. 保定市第一中心医院病理科,河北保定071000
- 2. 新疆生产建设兵团第二师库尔勒医院病理科,新疆库尔勒841000
- 折叠
摘要
Abstract
Objective:To study the expression and clinical significance of runt-related transcription factor 2 (Runc2) in breast carcinoma.Methods:The expression of Runx2 in primary breast invasive ductal carcinoma (IDC) and adjacent mammary gland tissue and its relationship with breast cancer's clinical pathological features was detected by immunohistochemical method (IHC).Results:IHC analysis showed that the positive expression rate of Runx2 in IDC was 69.52％ (73/105),much higher than that in para-tumor breast tissues [8.57％ (9/105),P＜0.05] and the expression of Runx2 in IDC was negatively related with estrogen receptor (ER).Furthermore,Runx2 expression showed a significant correlation with histopathologic grade lymph node metastasis and pTNM stage,and did not correlate with patients' age,and tumor size.Conclusion:The overexpression of Runx2 may participate in the tumorigenesis of breast carcinoma and may play a more important role in the carcinogenesis of ER negative expressing breast carcinoma.Runx2 correlated with malignant degree,invasion and metastasis of breast carcinoma and may be a key factor to assess the prognosis of patients.关键词
乳腺癌/成骨细胞特异性转录因子2/免疫组织化学Key words
breast carcinoma/runt-related transcription factor 2/immunohistochemistry引用本文复制引用
周炳娟,黄丽娟,曹建江,马小乐,孙吉瑞,乔海芝,赵文明,张金库..成骨细胞特异性转录因子2在乳腺癌中的表达及临床意义[J].国际病理科学与临床杂志,2017,37(1):50-55,6.
