摘要
Abstract
Objective:To explore the diagnostic value of BISAP scores combined with serum cholinesterase in patients with critical acute pancreatitis (AP).Methods:A total of 164 patients with AP from Jan.2014 to Jun.2016 were selected,including 52 patients with mild AP,76 patients with moderate AP,16 patients with severe AP and 20 cases with critical AP.The BISAP scores and level of serum cholinesterase among different kinds of AP were compared.Meanwhile,the area under ROC curve (AUC) was used to predict the presence of critical AP and the difference of diagnostic value between BISAP scores combined with serum cholinesterase and single application were compared.Results:With the degree of severity ofAP,BISAP scores gradually increased and levels of serum cholinesterase declined.The differences of BISAP scores and levels of serum cholinesterase among different kinds of AP were significant (All P＜0.05).The AUC of BISAP scores for critical AP was 0.881 (95％ CI:0.795-0.968),when the cutoff value was 2.5,the sensitivity,specificity and accuracy were 90.0％,79.2％ and 80.5％.The AUC of serum cholinesterase for critical AP was 0.791 (95％ CI:0.668-0.914),when the cutoff value was 3 406 U/L,the sensitivity,specificity and accuracy were 85.0％,74.3％ and 75.6％.Logistic regression was obtained by BISAP scores and serum cholinesterase regression model.The sensitivity,specificity and accuracy of BISAP scores combined with serum cholinesterase were 90.0％,87.8％ and 89.6％.The differences of AUC between BISAP scores combined with serum cholinesterase and single application were significant (All P＜0.05).Conclusion:BISAP scores and serum cholinesterase can accurately diagnose critical AP.When they are combined,the diagnosis efficacy of critical AP can increase.关键词
胰腺炎/BISAP评分/胆碱酯酶/诊断Key words
pancreatitis/bedside index for severity in AP/cholinesterase/diagnose
