摘要
Abstract
Objective: To investigate the histological and immunohistochemical features of 29 cases of epithelioid gastrointestinal stromal tumors (GIST), as well as the diagnosis and differential diagnosis, which is of great clinical significance for the clinical correct diagnosis, treatment and prognosis. Methods: A total of 321 cases of GISTwere retrospectively analyzed from March, 2009 to August, 2016. Twenty-nine cases of epithelioid GIST werescreened and re-examined. Results: Among 29 cases of epithelioid GIST, there were 15 cases of stomach, 2 casesof small intestine, 3 cases of mesentery, 4 cases of rectum, 3 cases of abdominal cavity, 1 case of retroperitoneumand 1 case of pelvic cavity. There were 25 cases of malignant GIST and 4 cases of benign. Tumor cells were rich,cytoplasmic was eosinophilic or transparent, the nuclear ratio of some tumor cells was high, nuclear size rangedand was polymorphic, more mitotic, accompanied by focal coagulation necrosis, interstitial cells were mostassociated with myxoid degeneration. The structures of tissue were organ-like, flake, nest and alveolar shape, etc.Immunohistochemical staining of CD34 and DOG-1 was positive in epithelioid GIST (positive rate 100%) andCD117 (positive rate 86%). Conclusion: Epithelioid GIST is widely distributed in many parts of the body, and itis easy to misdiagnose other epithelial-like tumors. Immunohistochemical staining of CD34, DOG-1 and CD117is of great value in the diagnosis and differential diagnosis of epithelioid GIST, such as tumor mass, cell-rich,nuclear division, and mucinous stromal degeneration; the vast majority should consider the malignant GIST, so asto provide an important guiding significance for clinical correct diagnosis and treatment.关键词
上皮样胃肠间质瘤/病理诊断及鉴别诊断/免疫组织化学Key words
epithelioid gastrointestinal stromal tumor/pathological diagnosis and differential diagnosis/immunohistochemistry
