临床与病理杂志2017，Vol.37Issue(3)：456-461,6.DOI:10.3978/j.issn.2095-6959.2017.03.002
PD-1及其配体在原发性干燥综合征患者唇腺中的表达及临床意义
Expression and clinical significance of PD-1 and its ligands in salivary glands of patients with Sjogren's syndrome
摘要
Abstract
Objective: To investigate the expression and its relativity with the clinicopathological characteristics of programmed death-1 (PD-1) and its ligands PD-L1 and PD-L2 in salivary glands of patients with Sjogren's syndrome (SS). Methods: We used HE staining to observe the lymphocyte infiltration while used immunohistochemistry to observe the expression of PD-1, PD-L1 and PD-L2 in both patients' and normal-controlled group's salivary glands biopsies. Results: The expression of PD-1, PD-L1 and PD-L2 in salivary glands biopsies of patients with SS significantly enhanced compared with the normal-controlled group. There were no significant relevance between the lymphocyte infiltration and the expression degrees of PD-1 and PD-L2 in salivary glands biopsies of patients with SS. However, lymphocyte infiltration had positive correlation with the expression degrees of PD-L1 in salivary glands biopsies of patients with SS. There were no significant relevance between the disease activity index of patients with SS and the expression degree of PD-1, PD-L1 and PD-L2. There was no significant relevance between the disease damage index of patients with SS and the expression degree of PD-1, while the disease damage index was negatively correlated with the expression degree of PD-L1 and PD-L2. Conclusion: The expression of PD-1, PD-L1 and PD-L2 significantly enhance in salivary glands biopsies of patients with SS. Therefore, PD-1/PD-L pathway may play a big role in immune pathological damage of SS.关键词
原发性干燥综合征/程序性死亡分子-1/程序性死亡配体Key words
Sjogren's syndrome/programmed death-1/programmed death ligands引用本文复制引用
杨月,侯佳奇,李国陵,薛鸾,张树辉..PD-1及其配体在原发性干燥综合征患者唇腺中的表达及临床意义[J].临床与病理杂志,2017,37(3):456-461,6.基金项目
上海市卫生局课题(20111016).This work was supported by the Project of Shanghai Health Bureau, P. R. China (20111016). （20111016）
