国际病理科学与临床杂志2017，Vol.37Issue(3)：462-466,5.DOI:10.3978/j.issn.2095-6959.2017.03.003
微结节性胸腺瘤伴淋巴样间质3例临床病理观察
Clinicopathological observation of three cases of micronodular thymoma with lymphoid stroma
朱长仁 1顾学文 1肖芹 1张子兰 1徐清 1周志毅2
作者信息
- 1. 江苏省苏北人民医院病理科,江苏 扬州 225001
- 2. 无锡市人民医院病理科,江苏 无锡 214023
- 折叠
摘要
Abstract
Objective: To investigate the clinicopathological characteristics of micronodular thymoma with lymphoid stroma (MNT). Methods: The clinicopathological characteristics and the related literature of three cases of MNT were studied by histopathological and immunohistochemical techniques. Results: All patients were asymptomatic and their thymus tumors were located in the anterior mediastinum. Histologically, the tumors with fibrous pseudocapsule were comprised of sporadic or mixed epithelioid nodules, which separated by abundant lymphoid stroma with folliculi lymphaticus. The nodules were consisted of neoplastic spindle cells in which there were not obvious nucleolus and fewer lymphocytes. Immunohistochemical studies showed positivity of the spindle tumor cells for CKpan, CK5/6, CKl9, CK8/18, Ki67 (2%) and stains for CD20, EMA were negative. Lymphocytes in the septum showed positivity for CD20, CD3, CD5, CD99, P53, CD1α, TdT. Lymphocytes in the background showed negativity for CK5/6, C8/18, EMA. Conclusion: Now MNT belongs to borderline tumor in WHO. MNT is very unusual but can be diagnosed with the characteristic morphology and immunoreactivity.关键词
胸腺肿瘤/微结节性胸腺瘤伴淋巴样间质/临床病理/免疫组织化学Key words
thymus neoplasm/micronodular thymoma with lymphoid stroma/clinicopathology/immunohistochemistry引用本文复制引用
朱长仁,顾学文,肖芹,张子兰,徐清,周志毅..微结节性胸腺瘤伴淋巴样间质3例临床病理观察[J].国际病理科学与临床杂志,2017,37(3):462-466,5.
