临床与病理杂志2017，Vol.37Issue(3)：478-484,7.DOI:10.3978/j.issn.2095-6959.2017.03.006
23例仅C3沉积的儿童原发性肾病的临床病理特征
Clinical manifestations and pathological features of 23 primary glomerulonephritis children with isolated C3 deposits
摘要
Abstract
Objective: To deeply understand clinical and pathological characteristics of primary glomerulonephritis children with C3 deposits through a retrospective analysis. Methods: Primary glomerulonephritis children with the C3 deposits diagnosed by renal biopsy in our hospital were selected. Clinicopathological features, renal functions,laboratory tests including C3 and C4, and pathological information were collected. Treatment and follow-up were recorded. Results: Twenty-three cases was involved, including 7 cases with acute post-streptococcal glomerulonephritis, 6 cases with nephritis syndrome, 7 cases with nephrotic syndrome, 3 cases with recurrent macroscopic haematuria, C3 decreased in 20 cases. Pathological manifestations of capillaries proliferative glomerulonephritis was in 11 cases, focal proliferative glomerulonephritis in 1 case, crescent nephritis in 1 case, sclerosing glomerulonephritis in 6 cases, and membrane proliferative glomerulonephritis in 4 cases. Pathological immune fluorescence intensity of C32+ were in 9 cases, 3+ in 14 cases. Immune complex deposition were all visible at subcutaneous, under the epithelium, mesangial area. Children were given positive treatment according to clinical manifestations. Most of cases recovered well. Conclusion: Clinical and pathological manifestations varied in children with primary glomerulonephritis with isolated C3 deposits. Prognosis is associated with pathological changes.关键词
C3沉积/C3肾小球肾炎/补体/儿童Key words
C3 deposits/C3 glomerulonephritis/complement/children引用本文复制引用
周楠,沈颖,孙嫱,周春菊,孟群,樊剑锋,陈植,刘小荣..23例仅C3沉积的儿童原发性肾病的临床病理特征[J].临床与病理杂志,2017,37(3):478-484,7.基金项目
首都临床特色应用研究(Z161100000516106) （Z161100000516106）
首都医科大学基础-临床科研合作基金(14JL76).This work was supported by the Capital Characteristic Clinical Application Research (Z161100000516106) （14JL76）
Base-Clinical Scientific Research Cooperation Fund of the Capital Medical University, P. R. China (14JL76). （14JL76）
