临床与病理杂志2017，Vol.37Issue(3)：564-569,6.DOI:10.3978/j.issn.2095-6959.2017.03.020
LASS2在鼻咽癌中的表达及其意义
Expression of LASS2 in nasopharyngeal carcinoma
摘要
Abstract
Objective: To investigate the role of the expression of LASS2 on the occurrence and development of nasopharyngeal carcinoma (NPC). Methods: A total of 127 cases of NPC in total, including stageⅠ 12 cases (group A), stage Ⅱ 26 cases (group B), stage Ⅲ 52 cases (group C), stage Ⅳ 27 cases (group D), and 49 cases of chronic nasopharyngitis (group E), were collected in our hospital from Jun. 2011 to Dec. 2014. The expression of LASS2 was evaluated by immunohistochemical. The associations between the expression of LASS2 and the clinicopathological parameters of NPC patients were statistically analyzed. Results: The expression of LASS2 in NPC (from group A to group D were 75%, 73.1%, 78.8% and 81.1%) were significantly lower than chronic nasopharyngitis (group E was 100%) (P=0.008). Recurrence of NPC was related to low expression of LASS2 (P=0.001). However, the disease-free survival in LASS2 positive group was similar to LASS2 negative group (P>0.05). Conclusion: LASS2 is one kind of tumor suppressor gene. Its encoding protein express in non-tumor nasopharyngeal tissues. LASS2 protein may be lost during the occurrence of NPC. Similarly, recurrence of NPC may be related to the loss of LASS2 protein. LASS2 may be a valuable predictor for recurrence of NPC.关键词
鼻咽癌/LASS2/复发/抑癌基因Key words
nasopharyngeal carcinoma/LASS2/relapse/tumor suppressor gene引用本文复制引用
王见璋,黄金凤,李炜霞,何志明,黄景彬,周璐,郭楚泳,蔡桂荣,申洪..LASS2在鼻咽癌中的表达及其意义[J].临床与病理杂志,2017,37(3):564-569,6.基金项目
广东省佛山市医学类科技攻关项目(2015AB002613).This work was supported by Project of Foshan Medical Science and Technology, Guangdong Province, P. R. China (2015AB002613). （2015AB002613）
