临床与病理杂志2017，Vol.37Issue(3)：600-607,8.DOI:10.3978/j.issn.2095-6959.2017.03.027
58例肺肉瘤样癌的临床特征与预后因素
Clinical features and prognostic factors of 58 cases of pulmonary sarcomatoid carcinoma
摘要
Abstract
Objective: To investigate the characteristics of pulmonary sarcomatoid carcinoma (PSC) and analyze the prognostic factors. Methods: Fifty-eight patients with PSC were retrospectively reviewed on the clinical data, immunohistochemistry and genetic state, and the survival rate was calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates. Univariate and multivariate factors for survival were analyzed by Cox proportional hazards regression model. Results: Fifty-eight cases of PSC were men, <65 years old and smoking patients predominant; COX univariate analysis revealed that gender, age, smoking history, EGFR gene status, ALK fusion gene status, stage, histologic subtype were prognostic factors for PSC. COX multivariate analysis found that ALK fusion gene status, histologic subtype were independent prognostic factors for PSC (P<0.05). Conclusion: There is no specificity in the clinical characteristics of PSC and its successful diagnosis depends on pathological and immunohistochemical analysis. ALK fusion status and histologic subtype are the crucial prognostic factors for PSC.关键词
肺肉瘤样癌/EGFR基因/ALK基因/突变率/预后Key words
pulmonary sarcomatoid carcinoma/EGFR gene/ALK gene/mutation rate/prognosis引用本文复制引用
黄韵坚,庄武,许春伟,陈刚,钟礼花,陈芳芳,陈燕坪,黄章洲,卢建平,王晓江,师怡,林贤东..58例肺肉瘤样癌的临床特征与预后因素[J].临床与病理杂志,2017,37(3):600-607,8.基金项目
国家临床重点专科建设项目(2013) （2013）
福建省科技厅引导性项目(2015Y0011) （2015Y0011）
福建省科技厅引导性项目(2016Y0019).This work was supported by National Clinical Key Specialty Construction Program (2013) （2016Y0019）
Leading Project Foundation of Science Department of Fujian Province (2015Y0011) （2015Y0011）
Leading Project Foundation of Science Department of Fujian Province, P. R. China (2016Y0019). （2016Y0019）
