广西科学2017，Vol.24Issue(1)：1-6,6.DOI:10.13656/j.cnki.gxkx.20170119.002
计算机辅助蛋白结构预测及酶的计算设计研究进展
A Brief Overview of Computational Protein Structure Prediction and Enzyme Design
摘要
Abstract
With the dwindling of the non-renewable resources and increasingly serious problems of environmental pollution caused by chemical catalysis,enzyme-based technologies with low pollution emission are poised to transform the traditional chemical industry and become highly important in the strategy of sustainable development.As important biological catalysts,enzymes have great application potential and good development prospect in the fields of chemical industry and medicine due to their ability to catalyze reactions with high catalytic efficiency and specificity.However,the application scope of enzymes is restricted by the low discovery rate.Along with the development of computer technology,computational protein structure prediction and enzyme design are becoming powerful tools of tailoring enzymes for specific biotechnological applications.This review addresses various strategies of the protein structure prediction and "inside out" enzyme design methods.Finally,the challenges of computational enzyme design are reviewed.关键词
生物催化/三维结构预测/计算酶功能设计Key words
biomolecular catalysis/structure prediction/computational enzyme design分类
生物科学引用本文复制引用
崔颖璐,吴边..计算机辅助蛋白结构预测及酶的计算设计研究进展[J].广西科学,2017,24(1):1-6,6.基金项目
国家自然科学基金项目(21603013)和中国博士后科学基金项目(2016M591090)资助. （21603013）
