广西师范大学学报（自然科学版）2016，Vol.34Issue(4)：151-155,5.DOI:10.16088/j.issn.1001-6600.2016.04.023
慢性吸烟者的脑静息态fMRI局部一致性研究
Alterations in Regional Homogeneity of Resting-state Brain Activity in Chronic Cigarette Smokers
摘要
Abstract
Most previously studies on chronic smokers are transversal studies based on task paradigm.In this study,longitudinal studies of regional brain activity alterations between smoking and quitting smoking for some time in resting state are carried.Twelve healthy chronic smokers participated in this study and were imaged with resting state functional magnetic resonance imaging (fMRI) in two stages,i.e.,under smoking and after quitting smoking for one week.Then regional homogeneity (ReHo) method was used to conduct a comparative analysis of the statistics of the two stages.Compared with those in smoking state,smokers who had quitted smoking for one week showed decreased level of ReHo in frontal lobe (orbital,medial,middle),left precuneus,left posterior cingulate cortex (PCC),left cuneus,and right supplementary motor area,as well as increased level of ReHo in bilateral superior temporal gyrus,left calcarine,left lingual gyrus,left fusiform gyrus,left parahippocampa gyrus,right postcentral gyrus,and left putamen.The results indicate that coherence of neural activities have been altered in the above brain regions after quitting smoking for one week among the chronic smokers,which offers references for the application of ReHo in smoking cessation therapy.关键词
慢性吸烟/静息态功能磁共振成像/局部一致性/戒烟Key words
chronic smokers/resting-state fMRI/regional homogeneity/smoking cessation分类
医药卫生引用本文复制引用
刘佳丽,王冬翠,莫少锋,李宏周,陈真诚..慢性吸烟者的脑静息态fMRI局部一致性研究[J].广西师范大学学报（自然科学版）,2016,34(4):151-155,5.基金项目
国家自然科学基金资助项目(61271119) （61271119）
国家科技支撑计划基金资助项目(2013BAI03B01) （2013BAI03B01）
