海南医学院学报2017，Vol.23Issue(5)：593-595,599,4.DOI:10.13210/j.cnki.jhmu.20161221.012
早期康复训练对急性脑梗死患者血清NGF、NSE、BDNF及运动功能的影响
Effect of early rehabilitation training on the serum NGF, NSE, BDNF, and motor function in patients with acute cerebral infarction
摘要
Abstract
Objective: To explore the effect of early rehabilitation training on the serum NGF, NSE, BDNF, and motor function in patients with acute cerebral infarction (ACI).Methods: A total of 150 patients with ACI who were admitted in our hospital from October, 2015 to October, 2016 were included in the study and randomized into the observation group and the control group.The patients in the two groups were given anti-coagulation, anti-platelet aggregation, cerebral circulation improving, and brain cell activators.The patients in the control group were given routine neurological nursing, while the patients in the observation group were given early comprehensive rehabilitation training on the basis of stable vital signs and no disease progression within 48 h.The morning fasting peripheral venous blood before treatment, 2 and 4 weeks after treatment in the two groups was collected.The serum NGF, NSE, BDNF, IL-6, hs-CRP, and TNF-α were detected.The activities of daily living and motor function before treatment, 2 and 4 weeks after treatment in the two groups were evaluated.Results: IL-6, hs-CRP, and TNF-α levels 2 and 4 weeks after treatment in the observation group were significantly lower than those in the control group (P<0.05).NGF and BDNF levels 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05), while NSE level was significantly lower than that in the control group (P<0.05).MBI and FMA scores 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05).Conclusions: The early rehabilitation training can effectively reduce the inflammatory reaction of nervous system in patients with ACI, regulate NGF, BDNF, and NSE levels, and play the cerebral function remodeling in order to promote the neural function recovery, and improve the motor function.关键词
急性脑梗死/早期康复训练/NGF/NSE/BDNF/运动功能Key words
Early rehabilitation training/ACI/NGF/NSE/BDNF/motor function分类
医药卫生引用本文复制引用
崔振平..早期康复训练对急性脑梗死患者血清NGF、NSE、BDNF及运动功能的影响[J].海南医学院学报,2017,23(5):593-595,599,4.基金项目
河北省科学计划项目(101461103) （101461103）
The study was supported by the Scientific Planning Project of Hebei Province with the number of 101461103. （）
