海南医学院学报2017，Vol.23Issue(5)：623-626,4.DOI:10.13210/j.cnki.jhmu.20161216.007
炎症损伤和氧化应激损伤对糖尿病肾病患者尿微量白蛋白/肌酐、24h尿微量白蛋白的影响
Effect of inflammatory injury and oxidative stress injury on urine microalbumin/creatinine and 24 h urine microalbumin in patients with diabetic nephropathy
摘要
Abstract
Objective: To explore the effect of inflammatory injury and oxidative stress injury on urine microalbumin/creatinine (UACR) and 24 h urine microalbumin (24hUMA) in patients with diabetic nephropathy.Methods: A total of 54 patients with early diabetic nephropathy treated in our hospital between June 2012 and December 2015 were included in early DN group and 60 patients with clinical diabetic nephropathy were included in clinical DN group.A total of 50 healthy subjects who received physical examination in our hospital during the same period were included in healthy control group.Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum inflammatory injury index levels;automatic biochemical analyzer was used to determine serum oxidative stress injury index levels;immunoturbidimetry was used to detect 24 hUMA, and UACR level was calculated.Results: Serum IL-6, IL-18, IL-27 and TNF-α levels of clinical DN group were significantly higher than those of early DN group and healthy control group while IL-10 level was significantly lower than that of early DN group and healthy control group (P<0.05);serum T-AOC, VitC and GSH-Px levels were significantly lower than those of early DN group and healthy control group while LHP and MDA levels were higher than those of early DN group and healthy control group (P<0.05);UACR and 24 hUMA levels were significantly higher than those of early DN group and healthy control group (P<0.05).Spearman correlation analysis showed that UACR and 24hUMA levels in patients with diabetic nephropathy were directly related to the degree of inflammatory injury and oxidative stress injury.Conclusions: The inflammatory injury and oxidative stress injury directly affect the UACR and 24hUMA levels in patients with diabetic nephropathy, and are the important determinants for the occurrence and development of disease.关键词
糖尿病肾病/炎症损伤/氧化应激/尿微量白蛋白/24h尿微量白蛋白Key words
Diabetic nephropathy/Inflammatory injury/Oxidative stress/Urine microalbumin/24 h urine microalbumin分类
医药卫生引用本文复制引用
孙晓兰,陈敏..炎症损伤和氧化应激损伤对糖尿病肾病患者尿微量白蛋白/肌酐、24h尿微量白蛋白的影响[J].海南医学院学报,2017,23(5):623-626,4.基金项目
上海市卫生局科研课题计划项目(20130112) （20130112）
It is supported by Scientific Research Planning Project of Shanghai Health Bureau(20130112). （20130112）
