海南医学院学报2017，Vol.23Issue(5)：627-630,4.DOI:10.13210/j.cnki.jhmu.20161216.004
子痫前期患者血清中sEng、ADMA含量与胎盘缺氧损伤、细胞凋亡的相关性
The correlation of serum sEng and ADMA levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia
摘要
Abstract
Objective: To study the correlation of serum sEng and ADMA levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia.Methods: A total of 56 patients diagnosed with preeclampsia in our hospital between May 2014 and March 2016 were selected as PE group, healthy subjects giving birth during the same period were selected as control group, serum was collected to determine sEng and ADMA levels, and the placenta tissue was collected to determine the levels of oxidative stress indexes and cell apoptosis molecules.Results: Serum sEng and ADMA levels of PE group were significantly higher than those of control group;SOD, GSH-Px, CAT, SVCT1, SVCT2, Survivin and XIAP levels in placenta tissue of PE group were significantly lower than those of control group while Beclin1 and LC3-Ⅱ/LC-Ⅰ ratio were significantly higher than those of control group;Beclin1 and LC3-Ⅱ/LC-Ⅰ ratio in placenta of patients with high sEng and ADMA levels within PE group were significantly higher than those of patients with low sEng and ADMA levels while SOD, GSH-Px, CAT, SVCT1, SVCT2, Survivin and XIAP levels were significantly lower than those of patients with low sEng and ADMA levels.Conclusions: Serum sEng and ADMA levels in patients with preeclampsia increase significantly and are closely related to the placental hypoxia injury and cell apoptosis.关键词
子痫前期/可溶性Endoglin/非对称性二甲基精氨酸/氧化应激/凋亡Key words
Preeclampsia/Soluble endoglin/Asymmetric dimethylarginine/Oxidative stress分类
医药卫生引用本文复制引用
向兰花,周小峰,钟敏..子痫前期患者血清中sEng、ADMA含量与胎盘缺氧损伤、细胞凋亡的相关性[J].海南医学院学报,2017,23(5):627-630,4.基金项目
深圳市科技计划项目(JCYJ20160426094126651) （JCYJ20160426094126651）
It is supported by Science and Technology Planning Project of Shenzhen City (JCYJ20160426094126651). （JCYJ20160426094126651）
