海南医学院学报2017，Vol.23Issue(5)：631-634,4.DOI:10.13210/j.cnki.jhmu.20161216.008
阿托伐他汀联合曲美他嗪对冠心病患者心功能、氧化应激及炎症因子的影响
Effect of atorvastatin combined with trimetazidine on heart function, oxidative stress and inflammatory factors in patients with coronary heart disease
摘要
Abstract
Objective: To investigate the effects of atorvastatin combined with trimetazidine on heart function, oxidative stress and inflammatory factors in patients with coronary heart disease, Methods: A total of 110 patients with coronary heart disease from June 2015 to June 2016 in our hospital were selected as the research objects, randomly divided into observation group 55 cases and control group 55 cases.The patients in both groups received conventional treatment of coronary heart disease;the control group was given orally atorvastatin calcium capsules at the same time;the observation group was added with trimetazidine hydrochloride tablets on the basis of the control group.The LVESD, LVEDD, LVEF, CRP, TNF-α, IL-6, SOD and MDA levels of two groups respectively before and after treatment were compared.Results: Before treatment, the LVESD, LVEDD and LVEF levels between observation group and the control group had no significant difference (P>0.05);compared with before treatment, LVESD and LVEDD levels in the observation group and control group after treatment were significantly decreased and LVEF increased significantly (P<0.05);after treatment, LVESD, LVEDD of the observation group were significantly lower than the control group while LVEF in the observation group after treatment was significantly higher than the control group (P<0.05).Before treatment ,SOD and MDA between the observation group and the control group had no significant difference (P>0.05);after treatment, SOD in the observation group and the control group were significantly increased and MDA decreased significantly (P<0.05);after treatment, SOD in the observation group was significantly higher than the control group and MDA in the observation group was significantly lower than the control group (P<0.05).Before treatment, CRP, TNF-α, IL-6 between the observation group and the control group had no significant difference (P>0.05);compared with before treatment, the CRP, TNF-α, IL-6 of observation group and control group after treatment were significantly decreased (P<0.05);after treatment, CRP, TNF-α, IL-6 of the observation group were significantly lower than the control group (P<0.05).Conclusions: Atorvastatin combined with trimetazidine can more significantly improve cardiac function in patients with coronary heart disease, and reduce oxidative stress and inflammation.关键词
冠心病/阿托伐他汀/曲美他嗪/心功能/氧化应激/炎症因子Key words
Atorvastatin/Trimetazidine/Coronary heart disease/Heart function/Oxidative stress/Inflammation factor分类
医药卫生引用本文复制引用
易德茂,张娟,徐冬梅..阿托伐他汀联合曲美他嗪对冠心病患者心功能、氧化应激及炎症因子的影响[J].海南医学院学报,2017,23(5):631-634,4.基金项目
四川省卫生厅科研项目(161232) （161232）
It is supported by Scientific Research Project of Sichuan Provincial Health Department (161232). （161232）
