海南医学院学报2017，Vol.23Issue(5)：638-641,4.DOI:10.13210/j.cnki.jhmu.20161216.014
脓毒症患儿不同血糖水平对脏器损伤、氧化应激反应及Wnt5a炎症通路的影响
Effect of different blood glucose levels on viscera injury, oxidative stress response and Wnt5a inflammatory pathway in children with sepsis
摘要
Abstract
Objective: To investigate the effect of different blood glucose levels on viscera injury, oxidative stress response and Wnt5a inflammatory pathway in children with sepsis.Methods: A total of 70 children with sepsis treated in our hospital between January 2014 and December 2015 were retrospectively collected and divided into the sepsis group A (blood glucose >10 mmol/L) (n=29) and the sepsis group B (blood glucose ≤10 mmol/L) (n=41) according to the different blood glucose levels, and 50 healthy children who accepted vaccination and were with normal blood glucose levels in our hospital during the same period were selected as healthy control group.The day after admission, RIA method was used to determine liver function indexes;automatic biochemical analyzer was used to determine oxidative stress indexes;enzyme-linked immunosorbent assay (ELISA) was used to detect Wnt5a inflammatory pathway index levels.Results: Liver function indexes TBIL, ALT and AST levels of sepsis group A were significantly higher than those of sepsis group B and healthy control group (P<0.05);oxidative stress indexes AOPPs, LHP, ROS and MDA levels were significantly higher than those of sepsis group B and healthy control group while GSH-Px level was significantly lower than that of sepsis group B and healthy control group (P<0.05);serum Wnt5a inflammatory pathway indexes IL-1β, IL-6, IL-12 and MIP-1β levels were significantly higher than those of sepsis group B and healthy control group (P<0.05).Conclusions: Sepsis children with high blood glucose are with severe liver function damage as well as intense oxidative stress and inflammatory response, which are the important indexes for severe illness and poor prognosis.关键词
脓毒症/血糖水平/肝功能/氧化应激/Wnt5a炎症通路/儿童Key words
Sepsis/Blood glucose level/Liver function/Oxidative stress/Wnt5a inflammatory pathway分类
医药卫生引用本文复制引用
邹莉,方兴,梅文静..脓毒症患儿不同血糖水平对脏器损伤、氧化应激反应及Wnt5a炎症通路的影响[J].海南医学院学报,2017,23(5):638-641,4.基金项目
广东省惠州市科技计划项目(20130803) （20130803）
It is supported by Science and Technology Planning Project of Huizhou City, Guangzhou Province (20130803). （20130803）
