海南医学院学报2017，Vol.23Issue(5)：645-647,3.DOI:10.13210/j.cnki.jhmu.20161221.006
硝苯地平联合硫酸镁对妊娠期高血压患者血液流变学及凝血指标的影响
Effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension
摘要
Abstract
Objective: To explore the effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension.Methods: A total of 90 patients with gestational hypertension were included in the study and randomized into the observation group and the control group with 45 cases in each group.The patients in the observation group were given magnesium sulfate in combined with nifedipine, while the patients in the control group were only given magnesium sulfate.The patients in the two groups were continuously treated for 2 weeks.The blood pressure, hemorheology indicators, and coagulation indicators before and after treatment in the two groups were detected and compared.Results: SBP, DBP, whole blood high, moderate, and low shear viscosity, plasma viscosity, and HCT after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05).The levels of the above indicators after treatment in the observation group were significantly lower than those in the control group (P<0.05).PT, APTT, and TT after treatment in the two groups were significantly elevated when compared with before treatment (P<0.05), while Fib was significantly reduced (P<0.05).PT, APTT, and TT after treatment in the observation group were significantly higher than those in the control group (P<0.05), while Fib was significantly lower than that in the control group (P<0.05).Conclusions: Nifedipine in combined with magnesium sulfate can significantly stabilize the blood pressure level in patients with gestational hypertension, and improve the hemodynamic and coagulation indicators, with a significant efficacy.关键词
妊娠期高血压综合征/硫酸镁/硝苯地平/血压/血流变/凝血Key words
Gestational hypertension/Magnesium sulfate/Nifedipine/Blood pressure/Hemorheology/Coagulation分类
医药卫生引用本文复制引用
詹前美,陈坤,冯金,陈贤华..硝苯地平联合硫酸镁对妊娠期高血压患者血液流变学及凝血指标的影响[J].海南医学院学报,2017,23(5):645-647,3.基金项目
柳州市科技局基金(2011J0302034) （2011J0302034）
The study was supported by the Scientific and Technological Bureau Fund of Liuzhou City with the number of 2011J0302034. （）
