海南医学院学报2017，Vol.23Issue(5)：673-675,679,4.DOI:10.13210/j.cnki.jhmu.20161221.019
丹参注射液联合曲安奈德局部注射治疗OSF的疗效及对血清TGF-β1、IL-6的影响
Clinical efficacy of Danshen injection in combined with local injection of triamcinolone acetonide in the treatment of OSF and the effect on serum TGF-β1 and IL-6
摘要
Abstract
Objective: To explore the clinical efficacy of Danshen injection in combined with local injection of triamcinolone acetonide in the treatment of oral submucous fibrosis (OSF) and the effect on serum TGF-β1 and IL-6.Methods: A total of 70 patients with OSF who were admitted in our hospital from October, 2015 to October, 2016 were included in the study and randomized into the observation group and the control group.The patients in the control group were given multipoint injection of triamcinolone acetonide (40 mg/time) in the basal region of oral mucosal regions.On this basis, the patients in the observation group were given additional Danshen injection (4 mL/time), 1 time/week, for 12 times.VAS was used for evaluation.The oral mucosa lesion area and mouth opening were measured.The morning fasting peripheral venous blood before and after treatment in the two groups was collected.The blood rheometer was used to detect the whole blood viscosity [high shear (HS), moderate shear (MS), and low shear (LS)], plasma viscosity (PV), and fibrinogen (FIB).ELISA was used to detect the serum TGF-β1 and IL-6 levels.Results: VAS score in the observation group was significantly reduced (P<0.05), mucosal lesion area was significantly less than that in the control group (P<0.05), and mouth opening was significantly greater than that in the control group (P<0.05).LS, MS, PV, and FIB after treatment in the observation group were significantly reduced when compared with before treatment (P<0.05), while LS, MS, HS, PV, and FIB after treatment in the control group were not significantly changed (P>0.05).TGF-β1 and IL-6 levels after treatment in the observation group were significantly lower than those in the control group (P<0.05).Conclusions: Danshen injection in combined with local injection of triamcinolone acetonide in the treatment of OSF can effectively reduce the serum TGF-β1 and IL-6 levels, inhibit the connective tissue fibrosis, and improve the pain, oral mucosal lesion area, and mouth opening, with a satisfactory clinical effect.关键词
口腔黏膜下纤维性变/丹参注射液/曲安奈德/局部注射/TGF-β1/IL-6Key words
Danshen injection/Triamcinolone acetonide/Local injection/OSF/TGF-β1/IL-6分类
医药卫生引用本文复制引用
赵雁焕,徐梅,陆洋..丹参注射液联合曲安奈德局部注射治疗OSF的疗效及对血清TGF-β1、IL-6的影响[J].海南医学院学报,2017,23(5):673-675,679,4.基金项目
河北省医学科技进步获奖项目(151162-5-4) （151162-5-4）
The study was supported by the Medical Scientific and Technological Progress Awards Project of Hebei Province with the number of 151162-5-4. （）
