海南医学院学报2017，Vol.23Issue(5)：698-700,3.DOI:10.13210/j.cnki.jhmu.20161230.017
血清炎性因子及胰岛素样生长因子相关指标与妊娠期高血压疾病的相关性研究
Study on the correlation of serum inflammatory cytokine and insulin-like growth factor related indicators with hypertensive disorder complicating pregnancy
摘要
Abstract
Objective: To explore the correlation of serum inflammatory cytokine and insulin-like growth factor (IGF) related indicators with hypertensive disorder complicating pregnancy (HDP).Methods: A total of 90 patients with HDP who were admitted in our hospital from July, 2015 to July, 2016 for delivery were included in the study and divided into the pregnancy-induced hypertension group (n=43), mild preeclampsia group (n=28), and severe preeclampsia group (n=19).Moreover, 40 healthy puerpera who were admitted in the same period for delivery were served as the control group.The peripheral venous blood before delivery was collected.The immunoturbidimetry was used to detect hs-CRP.The radioimmunoassay was used to detect TNF-α and IL-6.ELISA was used to detect IGF-I, IGF-Ⅱ, and IGFBP-1.Results: The serum hs-CRP, TNF-α, and IL-6 levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly higher than those in the control group (P<0.05), and were gradually elevated with the further aggravation of the disease (P<0.05).The serum IGF-I and IGF-Ⅱ levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly lower than those in the control group (P<0.05), while IGFBP-1 level was significantly higher than that in the control group (P<0.05).With the further aggravation of the disease, IGF-I and IGF-II levels were gradually reduced (P<0.05), while IGFBP-1 level was gradually elevated (P<0.05).Conclusions: hs-CRP, TNF-α, IL-6, IGF-Ⅰ, IGF-Ⅱ, and IGFBP-1 are closely associated with the occurrence and development of HDP.关键词
妊娠期高血压疾病/炎性因子/胰岛素样生长因子结合蛋白/胰岛素样生长因子Key words
Inflammatory cytokine/IGFBP/IGF/HDP分类
医药卫生引用本文复制引用
王斌,白睿..血清炎性因子及胰岛素样生长因子相关指标与妊娠期高血压疾病的相关性研究[J].海南医学院学报,2017,23(5):698-700,3.基金项目
河北省科学技术成果获奖项目(20120150) （20120150）
The study was supported by the Scientific and Technological Achievement Awards Project of Hebei Province with the number of 20120150. （）
