海南医学院学报2017，Vol.23Issue(6)：736-738,742,4.DOI:10.13210/j.cnki.jhmu.20161228.001
SDF-1/CXCR4在膀胱癌组织中的表达及其与负性共刺激分子PD-L1、细胞凋亡和侵袭性的相关性研究
SDF-1/CXCR4 expression in bladder cancer tissue and the correlation with negative costimulatory molecule PD-L1,cell apoptosis and invasion
摘要
Abstract
Objective:To study the SDF-1/CXCR4 expression in bladder cancer tissue and the correlation with negative costimulatory molecule PD-L1,cell apoptosis and invasion.Methods:A total of 118 cases of bladder cancer tissue and para-carcinoma tissue surgically removed in our hospital between May 2014 and May 2016 were selected as the research samples,the RNA was extracted and then reverse-transcribed into cDNA,and the expression levels of SDF-1/CXCR4,PD-L1/PD-1,cell apoptosis-related molecules and cell invasion-related molecules were detected.Results:SDF-1 and CXCR4 mRNA expression in bladder cancer tissue were significantly higher than those in para-carcinoma tissue;PD-L1,PD-1,Rec1,Survivin,MRPS5,Nanog,BCAPP2Ac,TRPM8,TRPV2,ILK,β-catenin and GUGBP1 mRNA expression in bladder cancer tissue were significantly higher than those in para-carcinoma tissue and positively correlated with SDF-1 and CXCR4 mRNA expression.Conclusion:Highly expressed SDF-1/CXCR4 in bladder cancer tissue are closely related to the high expression of negative costimulatory molecule PD-L1,pro-proliferation molecules and pro-invasion molecules,and SDF-1/CXCR4 can promote the immune escape,proliferation and invasion of bladder cancer cells.关键词
膀胱癌/基质细胞衍生因子-1/趋化因子受体-4/免疫逃逸/增殖Key words
Bladder cancer/Stromal cell derived factor-1/Chemokine receptor-4/Immune escape/Proliferation分类
医药卫生引用本文复制引用
叶明宝,田俊强,常宏,杜昌国,燕群峰..SDF-1/CXCR4在膀胱癌组织中的表达及其与负性共刺激分子PD-L1、细胞凋亡和侵袭性的相关性研究[J].海南医学院学报,2017,23(6):736-738,742,4.基金项目
This study was supported by Shaanxi Provincial Health Department (2010H21) （2010H21）
陕西省卫生厅科研基金项目(2010H21) （2010H21）
