海南医学院学报2017，Vol.23Issue(6)：746-748,3.DOI:10.13210/j.cnki.jhmu.20160125.050
肺炎衣原体对颈动脉粥样硬化斑块患者单核巨噬细胞脂质代谢的影响
Analysis of the effect of Chlamydia pneumoniae on the lipid metabolism of mononuclear macrophages in patients with carotid atherosclerotic plaque
摘要
Abstract
Objective:To explore the effect of Chlamydia pneumoniae on the lipid metabolism of mononuclear macrophages in patients with carotid atherosclerotic plaque.Methods:A total of 90 patients with carotid atherosclerosis who were admitted in our hospital from January,2012 to December,2013 were included in the study and enrolled as the observation group,while 72 aged individuals who visited for physical examination served as the control group.The plaque formation in the two groups was observed and compared.The levels of TC,LDL-C,and HDL-C in the two groups were detected and compared.ELISA was used to detect CP IgG.The positive rate of CP IgG in the two groups was compared.Results:The multiple plaque,soft plaque,and mixed plaque in the observation group were significantly greater than those in the control group (P<0.05),but the difference in hard plaque between the two groups was not statistically significant (P>0.05).The levels of TC and LDL-C in the observation group were significantly higher than those in the control group,while HDL-C level was significantly lower than that in the control group (P<0.05).The positive rate of CP IgG in the observation group was significantly higher than that in the control group (P<0.05).Conclusions:Chlamydia pneumoniae has an important effect on the lipid metabolism of mononuclear macrophages in patients with carotid atherosclerotic plaque.关键词
肺炎衣原体/颈动脉粥样硬化/单核巨噬细胞Key words
Chlamydia pneumoniae/Carotid atherosclerosis/Mononuclear macrophages分类
医药卫生引用本文复制引用
曾庆娣,林爱翠..肺炎衣原体对颈动脉粥样硬化斑块患者单核巨噬细胞脂质代谢的影响[J].海南医学院学报,2017,23(6):746-748,3.基金项目
南京市医学科技发展项目(YKK14097) （YKK14097）
This study was supported by the Medical Scientific and Technological Development Project of Nanjing City with the number of YKK14097. （）
