海南医学院学报2017，Vol.23Issue(6)：809-812,4.DOI:10.13210/j.cnki.jhmu.20161223.005
食管癌组织中ERCC1和GSTP1表达量与铂类化疗药物敏感性及凋亡、增殖基因表达量的相关性
Correlation of ERCC1 and GSTP1 expression in esophageal cancer tissue with platinum-based chemotherapy sensitivity as well as apoptosis and proliferation gene expression
摘要
Abstract
Objective:To study the correlation of ERCC1 and GSTP1 expression in esophageal cancer tissue with platinum-based chemotherapy sensitivity as well as apoptosis and proliferation gene expression.Methods:Patients with advanced esophageal cancer who accepted PF chemotherapy in our hospital between May 2013 and October 2015 were selected,esophageal cancer tissue was collected before the chemotherapy,the patients were divided into chemotherapy sensitivity group and chemotherapy resistance group according to the effect of chemotherapy,and the expression levels of ERCC1,GSTP1 as well as apoptosis and proliferation genes in esophageal cancer tissue were detected.Results:Protein content and positive protein expression rate of ERCC1 and GSTP1 in esophageal cancer tissue of chemotherapy sensitivity group were significantly lower than those of chemotherapy resistance group,MBP1,DEC1 and PTEN protein content were significantly higher than those of chemotherapy resistance group,and PLCE1,CyclinD1 and PAR2 protein content were significantly lower than those of chemotherapy resistance group;MBP1,DEC1 and PTEN protein content in esophageal cancer tissue with positive ERCC1 and GSTP1 expression were significantly lower than those in esophageal cancer tissue with negative ERCC1 and GSTP1 expression while PLCE1,CyclinD1 and PAR2 protein content were significantly higher than those in esophageal cancer tissue with negative ERCC1 and GSTP1 expression.Conclusions:The highly expressed ERCC1 and GSTP1 in esophageal cancer tissue can decreased the cancer cell sensitivity to platinum-based chemotherapeutics,inhibit cell apoptosis and promote cell proliferation during platinum-based chemotherapy.关键词
食管癌/切除修复交叉互补基因1/凋亡/增殖Key words
Esophageal cancer/Excision repair cross complementing gene 1/Apoptosis/Proliferation分类
医药卫生引用本文复制引用
丁晓权,毕鑑红,马志刚,蒋占鑫,席俊峰,刘鹏,张志斌..食管癌组织中ERCC1和GSTP1表达量与铂类化疗药物敏感性及凋亡、增殖基因表达量的相关性[J].海南医学院学报,2017,23(6):809-812,4.基金项目
It is supported by Scientific Research Foundation of Shaanxi Province Anti-cancer Association （）
陕西省抗癌协会科研基金 （）
