海南医学院学报2017，Vol.23Issue(6)：827-830,833,5.DOI:10.13210/j.cnki.jhmu.20161223.009
微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响
Effect of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function injury and cytokine level in patients with hypertensive cerebral hemorrhage
摘要
Abstract
Objective:To study the effects of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function damage and cytokine level in patients with hypertensive cerebral hemorrhage.Methods:A total of 80 patients with hypertensive cerebral hemorrhage treated in our hospital between June 2010 and September 2015 were selected as the research subjects,the treatment methods and test results were reviewed,and then they were divided into the control group (n=45) who accepted minimally invasive evacuation of hematoma alone and the observation group (n=35) who accepted minimally invasive evacuation of hematoma combined with Xingnaojing therapy.Before and after treatment,cerebral blood flow detector was used to detect cerebral blood flow parameters;ELISA method was used to detect serum levels of neurological function indexes and inflammatory cytokines;high performance liquid chromatograph was used to detect serum neurotransmitter levels.Results:Before treatment,the differences in cerebral blood flow parameters,neurological function indexes,inflammatory cytokines and neurotransmitters were not statistically significant between two groups of patients (P>0.05).After treatment,cerebral blood flow parameters Q and V levels of observation group were higher than those of control group while R level was lower than that of control group (P<0.05);serum NSE,NPY,IL-1β,IL-4,IL-6,TNF-α,Glu and Asp contents of observation group were lower than those of control group while BDNF and Gly contents were higher than those of control group (P<0.05).Conclusion:Minimally invasive evacuation of hematoma combined with Xingnaojing therapy can improve the neurological function and regulate the synthesis of inflammatory cytokines and neurotransmitters in patients with hypertension cerebral hemorrhage.关键词
高血压脑出血/微创血肿清除术/醒脑静/神经功能/炎症因子Key words
Hypertension cerebral hemorrhage/Minimally invasive evacuation of hematoma/Xingnaojing/Neurological function/Inflammatory cytokines分类
医药卫生引用本文复制引用
李永峰,李伟..微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响[J].海南医学院学报,2017,23(6):827-830,833,5.基金项目
This study was supported by Jining municipal science and technology development plan projects [grant No.Jikezi (2011) 69] （2011）
济宁市科技发展计划项目[济科字(2011)69号] （2011）
