解放军医药杂志2017，Vol.29Issue(1)：31-34,4.DOI:10.3969/j.issn.2095-140X.2017.01.008
炎性反应和交感神经系统在慢性心力衰竭大鼠中枢调控中的相互作用
Interaction between Inflammatory Reaction and Sympathetic Nervous System in Central Regulation of Rats with Chronic Heart Failure
摘要
Abstract
Objective To investigate interaction between immune inflammatory reaction and sympathetic nervous system in central regulation of rats with chronic heart failure (CHF).Methods A total of 36 rats with chronic heart failure were randomly divided into sham operation group,coronary artery ligating group and central system intervention group (n =12 for each group).CHF models were established by ligating the anterior descending coronary artery method in coronary artery ligating and central system intervention groups,while sham operation group received braid without ligating.Central system intervention group was interfered by angiotensin Ⅱ type 1 (AT1) receptor blocker (Losartan) after operation.Levels of basal sympathetic activity,heart function,plasma catecholamine and inflammatory factor were detected in three groups.Results Compared with those in sham operation group,in CHF rats,sympathetic nerve activity levels were significantly enhanced,tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) levels in plasma and central system and norepinephrine (NE) levels in plasma were significantly increased (P ＜ 0.05),while heart function levels were decreased (P ＜ 0.05).Compared with those in coronary artery ligating group,in central system intervention group,sympathetic nerve activity,TNF-α and IL-1β levels in plasma,central system and NE levels in plasma were decreased (P ＜ 0.05),while cardiac function was significantly enhanced (P ＜ 0.05).Conclusion Inhibition of angiotensin level in central nervous system of CHF rats can reduce the excitability of the sympathetic system and immune inflammatory reaction during chronic heart failure and improve heart function.关键词
心力衰竭/交感神经系统/炎性细胞因子/大鼠,Sprague-DawleyKey words
Heart failure/Sympathetic nervous system/Inflammatory cytokines/Rats, Sprague-Dawley分类
医药卫生引用本文复制引用
周文秀,刘芳,杨俊..炎性反应和交感神经系统在慢性心力衰竭大鼠中枢调控中的相互作用[J].解放军医药杂志,2017,29(1):31-34,4.基金项目
武汉市临床医学科研项目(wx14c34) （wx14c34）
