解放军医学杂志2017，Vol.42Issue(3)：234-238,5.DOI:10.11855/j.issn.0577-7402.2017.03.11
舰船邻舱爆炸致比格犬脑损伤的实验研究
Experimental study on brain injury in Beagle dogs caused by adjacent cabin explosion in warship
摘要
Abstract
Objective Through the establishment of adjacent cabin blast injury model of Beagle dog,to investigate the pathophysiological changes in the experimental animals in this scenario,then speculate on the mechanisms of injury.Methods Several adjacent cabins were built in the same size with the real warship.Seven Beagle dogs were subjected to injuries from the explosion,from whom one was selected randomly to implant intracranial pressure transducers before blast,the others were tested on the pathophysiological changes after blast.The dogs were mounted on the platform of a cabinet in the adjacent cabin,subjected to injury from 650g bare TNT explosive blast.The transducers recorded the value of space and intracranial shock wave pressure.Following blast treatment,the serum levels of IL-6,IL-8,neuron specific enolase (NSE),brain and chest CT and pathological changes of the brain tissue were observed.Results Serum levels of IL-6,IL-8 and NSE were elevated to varying degrees after blast.All of them increased significantly at different time points after blast (P＜0.05).Brain and chest CT examinations did not show any significant positive results.Pathological results showed that there was a little necrosis in the brain,some neurons had karyopycnosis,karyolysis or disappearance of the nucleoli,and the cell boundaries were blurred.The blast wave was blocked greatly by the scalp and skull (about 90％),but could still penetrate them and cause brain injuries.Conclusions Explosion in the adjacent cabin causes mainly mild traumatic brain injuries.Blast wave can be blocked by the scalp and skull greatly.关键词
邻接舱室/爆震伤/脑损伤Key words
adjacent compartments/blast injuries/brain injuries分类
医药卫生引用本文复制引用
李彦腾,程岗,刘帅,刘邦鑫,王淑为,魏铂沅,王娟,张剑宁..舰船邻舱爆炸致比格犬脑损伤的实验研究[J].解放军医学杂志,2017,42(3):234-238,5.基金项目
国家自然科学基金(81372128) （81372128）
全军后勤科研重大项目(AHJ14J001)This work was supported by the National Natural Science Foundation of China (81372128),and the Major Projects of PLA Logistics (AHJ14J001) （AHJ14J001）
