吉林中医药2017，Vol.37Issue(2)：166-169,4.DOI:10.13463/j.cnki.jlzyy.2017.02.017
电针对WKY大鼠抑郁样行为及海马GluR1的影响
Effects of electroacupuncture on depressive behavior and hippocampal GluR1 of WKY rats
摘要
Abstract
Objective To observe the effects of electroacupuncture at "Baihui" and "yintang" on depressive behavior and hippocampal GluR1 of WKY rats.Methods 21 male WKY rats were randomly divided into EA group,sham EA group and model group;7 male Wistar rats served as normal group.EA group select "Baihui'and "yintang",Sham EA group were treated with placebo.Model group and normal group were fed regularly.Sucrose preference test(SPT) and forced swimming test(FST) were measured in rats after 21 d.Protein expression of glutamate receptors in rat hippocampus was detected by Western blot.Results After treatment,sucrose preference rate was significantly higher in EA group than sham EA group (P＜0.05),sucrose preference rate was significantly higher in normal group than model group(P＜0.05);In forced swimming test,the immobility time in the EA group and the normal group was less than sham EA group and model group (P＜0.05);The expression level of GluR1 in hippocampus was higher than sham group (P＜0.05),and the normal group was higher than model group (P＜0.01).Conclusion The depression-like behaviors of WKY depression models were improved by electroacupuncture treatment and the mechanism may be related to the increased expression of GluR1 in hippocampus.关键词
抑郁症/电针/行为学/WKY大鼠Key words
depression/electroacupuncture/behavior/WKY rats分类
医药卫生引用本文复制引用
陈泽钦,董波,黄丽,韩栩珂,徐世芬..电针对WKY大鼠抑郁样行为及海马GluR1的影响[J].吉林中医药,2017,37(2):166-169,4.基金项目
上海市教委科研创新重点项目(编号:2014zz116) （编号:2014zz116）
上海市卫生和计划生育委员会项目(编号:ZY3-CCCX-3-3022) （编号:ZY3-CCCX-3-3022）
