吉林中医药2017，Vol.37Issue(2)：180-183,4.DOI:10.13463/j.cnki.jlzyy.2017.02.021
黄瓜籽蛋白纤溶活性及抗凝溶栓作用研究
Study on fibrinolysin activity, anticoagulation and thrombolysis effects of cucumber seed
摘要
Abstract
Objective To investigate the effect of fibrinolysin activity,anticoagulation and thrombolysis of cucumber seed.Methods Fibrinolytic activity was estimated by fibrin plate method;Bleeding and coagulation time were measured on rats by means of blood sampling in the eyes and tail cutting;Through the establishment of carotid arterial thrombosis model on rats to study the thrombolysis effect from cucumber seed protein.Results The fibrinolysin activity of cucumber seed protein is (1 632.26±117.33) IU/g;The bleeding and coagulation time were significantly prolonged in the anticoagulant control group、high and medium dosage cucumber seed protein groups (P＜0.01),it is shown that cucumber seed protein have a good anticoagulant effect;The thrombolysis experiment result was shown that the wet weight of the thrombus were significantly lower on the rats in the anticoagulant control group,high,medium and low dose cucumber seed protein groups (P＜0.01),it is shown that cucumber seed protein have significant anti-arterial thrombosis effect.Conclusion Cucumber seed protein has significant activity on effects of fibrinolysin,anticoagulation and thrombolysis.关键词
黄瓜籽蛋白/纤溶酶活性/抗凝/溶栓Key words
cucumber seed protein/fibrinolysin activity/anticoagulation effect/thrombolysis effect分类
医药卫生引用本文复制引用
王萍,陈丽艳,孙银玲,张蕾,王天龙,王伟明..黄瓜籽蛋白纤溶活性及抗凝溶栓作用研究[J].吉林中医药,2017,37(2):180-183,4.基金项目
黑龙江省应用技术研究与开发计划新创办企业项目(编号:PB15F005) （编号:PB15F005）
哈尔滨市科技攻关计划项目(编号:2012DB3BS056). （编号:2012DB3BS056）
