军事医学2017，Vol.41Issue(3)：242-245,4.DOI:10.7644/j.issn.1674-9960.2017.03.019
尿酸相关基因及其多态性在疾病中的作用研究进展
Uric acid related gene and its genetic polymorphism function in diseases: a research progress
摘要
Abstract
Genome-wide association study (GWAS) has been increasing rapidly worldwide in recent years, along with more attention to heredity and genetic polymorphism of diseases.The single nucleotide polymorphism (SNP) is the most common genetic variant in the human genome, which can influence gene expression, transcription, translation and modification, and has become one of the important causes of disease susceptibility.Not only is uric acid related SNP susceptible to hyperuricemia and gout, but also plays an important role in the circulation, respiration, and nervous system diseases.Therefore, the present paper reviews the relationship between uric acid related SNP and clinical diseases in order to bring a new perspective on prevention and treatment.关键词
尿酸/单核苷酸多态性/阿尔茨海默病/高血压/非小细胞肺癌/糖尿病Key words
uric acid/single nucleotide polymorphism/Alzheimer's disease/hypertension/non-small cell lung cancer/diabetes mellitus分类
医药卫生引用本文复制引用
张园,刘雯辉,傅锐斌..尿酸相关基因及其多态性在疾病中的作用研究进展[J].军事医学,2017,41(3):242-245,4.基金项目
国家自然科学基金资助项目(8140120534) （8140120534）
