解放军医学院学报2016，Vol.37Issue(12)：1219-1222,4.DOI:10.3969/j.issn.2095-5227.2016.12.001
下咽及喉部鳞癌调强放疗致急性口腔黏膜炎的剂量因素分析
Dosimetric factors of IMRT-induced acute oral mucositis in squamous cell carcinoma of hypopharynx and larynx
摘要
Abstract
Objective To evaluate the correlation between acute oral mucositis and dosimetric factors in intensity-modulated radiotherapy (IMRI) in locally advanced squamous cell carcinoma of hypopharynx and larynx (LA-SCCH/L).Methods From August 1,2008 to December 31,2014,80 patients with LA-SCCH/L were treated by helical tomotherapy (HT) or RapidArc unit (RA),combined with concurrent cisplatin-based chemotherapy in our hospital.The related dosimetric factors were analyzed by receive operating characteristic (ROC) curve to detect the cutoff value of risk factors for the acute oral mucositis.Results No significant difference was found in the incidence of acute oral mucositis between HT and RA.Logistic analysis showed that oral V30 was independently associated with ≥ G2 mucositis (P =0.035) with a cut-off value of 42.4％ detected by ROC analysis.The incidence of ≥ G2 oral mucositis was 75％ (18/24) in patients with oral V30 ≥ 42.4％,and it was only 35.7％ in patients with oral V30 ＜ 42.4％ (20/56).Conclusion In the treatment of LA-SCCH/L,HT and RA are effective in protecting the normal tissues,without significant difference in acute oral mucositis.Oral V30 is related to acute oral mucositis.关键词
放射疗法,调强适形/黏膜炎/放射治疗剂量/口腔黏膜Key words
intensity-modulated radiotherapy/mucositis/radiotherapy dosage/oral mucosa分类
医药卫生引用本文复制引用
蔡博宁,戴相昆,徐寿平,陈高翔,宋明永,马林..下咽及喉部鳞癌调强放疗致急性口腔黏膜炎的剂量因素分析[J].解放军医学院学报,2016,37(12):1219-1222,4.基金项目
国家自然科学基金项目(11105225) （11105225）
解放军总医院临床科研扶持基金(2015FC-TSYS-2001)Supported by the National Natural Science Foundation of China(11105225) （2015FC-TSYS-2001）
