解放军医学院学报2016，Vol.37Issue(12)：1223-1227,5.DOI:10.3969/j.issn.2095-5227.2016.12.002
早期周围型非小细胞肺癌立体定向放疗临床疗效分析
Efficacy of stereotactic body radiotherapy in treatment of early-stage peripheral non-small cell lung cancer
摘要
Abstract
Objective To evaluate the clinical efficacy of stereotactic body radiotherapy in treatment of patients with early-stage peripheral non-small cell lung cancer (NSCLC).Methods A retrospective analysis of 40 newly diagnosed early stage (T1/T2N0M0) peripheral NSCLC patients treated with Cyberknife in Chinese PLA General Hospital from January 2012 to November 2014 was carried out.There were 9 women and 31 men with the median age of 74.5 years old (ranging from 43 to 90 years old).The primary outcome measurements included overall survival (OS) and progression-free survival (PFS),the secondary outcome measurements were objective response rate (ORR),disease control rates (DCR),local failure-free survival (LFFS),regional failure-free survival (RFFS) and no distant metastasis-free survival (DMFS),and the failure mode and adverse reactions were observed at the same time.Results The median follow-up was 28.5 months (range,7-44 months) with two cases lost to follow up.Complete response (CR) was achieved in 16 patients (42.1％),partial response (PR) in 7 patients (18.4％),stable disease (SD) in 9 patients (23.7％),and progressive disease (PD) in 8 patients (21.1％).The objective response rate (ORR) was 60.5％,and the primary tumor local control rate was 81.6％.One-year OS rate and three-year OS rate were 89.5％ and 83.3％ respectively for the entire group.One-year OS rate and three-year OS rate were 100.0％ and 100.0％ for T1 tumor,and 68.8％ and 45.8％ for T2 tumor,respectively (P=0.000).For the entire group,one-year PFS rate and three-year PFS rate were 88.6％ and 78.2％,one-year LFFS rate and three-year LFFS rate were 97.0％ and 89.5％,one-year DMFS rate and three-year DMFS rate were 91.5％ and 87.9％,respectively.Grade Ⅰ and grade 1 radiation pneumonitis were observed in 12 patients (31.6％) and 4 patients (10.5％),respectively.Grade Ⅰ fatigue was observed in 8 patients (21.1％),and grade Ⅲ or above adverse reaction was not found.Conclusion Cyberknife stereotactic radiotherapy provides a treatment option for early stage non-small cell lung cancer patients,with high local control rate,overall survival rate,distant disease control and low adverse reaction.关键词
立体定向放射治疗/射波刀/非小细胞肺癌Key words
stereotactic radiotherapy/cyberknife/non-small cell lung cancer分类
医药卫生引用本文复制引用
孟玲玲,邸玉鹏,蔡博宁,鞠忠建,王金媛,陈高翔,杜乐辉,马林,曲宝林..早期周围型非小细胞肺癌立体定向放疗临床疗效分析[J].解放军医学院学报,2016,37(12):1223-1227,5.基金项目
北京市首都临床特色应用研究(Z131107002213023) （Z131107002213023）
解放军总医院临床科研扶持基金(2012FC-TSYS-2016) Supported by the Study on the Application of Capital,Clinical Characteristics(Z131107002213023) （2012FC-TSYS-2016）
