解放军医学院学报2016，Vol.37Issue(12)：1241-1244,4.DOI:10.3969/j.issn.2095-5227.2016.12.006
耐甲氧西林与甲氧西林敏感金黄色葡萄球菌血流感染的临床特征与耐药性分析
Clinical characteristics of MRSA and MSSA bloodstream infection and their drug resistance
摘要
Abstract
Objective To investigate the clinical characteristics of bloodstream infection of methicillin resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) and their antimicrobial susceptibility test results.Methods From January 2010 to December 2014,clinical and microbial data of patients admitted to Chinese PLA General Hospital for Staphylococcus aureus bloodstream infection were collected.Chi-square test was perfomed to analyze the clinical characteristics and drug resistance between MRSA and MSSA bloodstream infection.Results One hundred and eighty-three patients were recruited,including 118 males and 65 females with average age of (49.94 ± 15.73) years.MRSA accounted for 59.6％ in all of Staphylococcus aureus infections.MRSA also accounted for 50.8％ of all community-acquired Staphylococcus aureus bloodstream infection.There were significant differences in male/female ratio,history of cerebral infarction,infection site,history of recent surgery,morbidity of sepsis shock,admitted department and mortality between MRSA and MSSA bloodstream infection (P ＜ 0.05).Ampicillin/sulbactam,levofloxacin,rifampin were more susceptible to MSSA than MRSA (P ＜ 0.05).Conclusion MRSA plays an important role in Staphylococcus aureus bloodstream infection.The differences in clinical characteristics and drug-resistance between MRSA and MSSA bloodstream are significant,which are indicative for the diagnosis and treatment on Staphylococcus aureus bloodstream infection.关键词
耐甲氧西林的金黄色葡萄球菌/血流感染/药物监测Key words
methicillin-resistant Staphylococcus aureus/bloodstream infection/drug monitoring分类
医药卫生引用本文复制引用
吴珍,王莉洁,喻航,杜明梅,粱志欣,陈良安..耐甲氧西林与甲氧西林敏感金黄色葡萄球菌血流感染的临床特征与耐药性分析[J].解放军医学院学报,2016,37(12):1241-1244,4.基金项目
部委级资助项目 （）
全军医学科技“十二五”科研项目(BWS11J057)Supported by the 12th Five Years Program for Medicine and Health Science Research of Chinese PLA(BWS11J057) （BWS11J057）
