Abstract
Objective To discuss the correlation between serum 25-hydroxyvitamin D level and peripheral neuropathy in type 2 diabetes mellitus(T2DM).Methods A total of 330 cases of T2DM in our hospital from March 2015 to March 2016 were selected and divided into the simple diabetic group(NDPN group,173 cases) and the diabetic complicating peripheral neuropathy group(DPN group,157 cases) based on clinical symptoms and limbs EMG;the gender,age,duration of diabetes,BMI,serum creatinine,uric acid,blood lipids[triglycerides(TG),total cholesterol(TC),high density lipoprotein(HDL-C),low-density lipoprotein(LDL-C)],glycated hemoglobin(HbA1c),parathyroid hormone(PTH),fibrinogen(FIB),fasting C-peptide,calcium,phosphorus and other indicators were compared between the two groups,as well as the level of serum 25-hydroxyvitamin D was detected and compared between the two groups;the vitamin D nutritional status in two groups were judged According to the results.And the correlation between 25-hydroxyvitamin D and other indicators was analyzed.Results The age,disease duration and HbA1c in the DPN group were significantly higher than those in the NDPN group,the difference was statistically significant(t≥3.073,P<0.05);the levels of FC and 25-(OH) D in the DPN group were significantly lower than those in the NDPN group,the difference was statistically significant(t≥3.567,P<0.05).The median nerve MCV,SCV,peroneal nerve MCV,SCV of superficial peroneal nerve in the DPN group were significantly lower than those in the NDPN group,the difference was statistically significant(t≥13.524,P<0.05).The Pearson correlation analysis results showed that the 25-hydroxyvitamin D level was negatively correlated with the DPN onset duration,the difference was statistically significant(r=-0.465,P<0.05),negatively correlated with HbA1c(r=-0.678,P<0.05) and positively correlated with the median nerve MCV and SCV,common peroneal nerve MCV and superficial peroneal nerve SCV(r=0.310,0 362,0.596 and 0.523,all P<0.05),had no correlation with the age,serum lipids and other indexes.The Logistic regression model results showed that the disease duration,HbA1c and 25-hydroxy vitamin D were all independent risk factors for complicating DPN,in which 25-hydroxyvitamin was one of the protective factors of DPN.Conclusion 25-hydroxy vitamin D and disease duration of DPN are correlated with HbA1c;25-hydroxy vitamin D deficiency is an independent risk factor for DPN,indicating that the supplement of DPN vitamin D may play a role in the prevention and treatment of diabetes complicating DPN.关键词
2型糖尿病/血清25-羟维生素D水平/周围神经病变Key words
type 2 diabetes/serum 25-hydroxyvitamin D levels/peripheral neuropathy
