摘要
Abstract
Objective To explore the expression of inflammatory cytokines(IL-1β,IL-6 and IL-18) in craniocerebral injury and its clinical significance.Methods A total of 163 patients with craniocerebral injury(craniocerebral injury group) in our hospital form December 2012 to December 2014 were selected,including 68 mild cases,49 moderate cases and 46 severe cases.Blood samples were collected on 0,1,4,7,15,30 d after injury.Other 57 healthy people were selected as the control group.The levels of IL-1β,IL-6 and IL-18 at each time point were detected by adopting the enzyme-linked immunosorbent assay.Results Compared with the control group and after treatment,the levels of IL-1β,IL-6 and IL-18 before treatment in the craniocerebral injury group were significantly increased,the difference was statistically significant(P<0.05);compared with the control group,the levels of IL-1β,IL-6 and IL-18 after treatment in the craniocerebral injury group had no statistical difference(P>0.05).The levels of IL-1β,IL-6 and IL-18 in the craniocerebral injury group were gradually increased from the admission,and reached to the highest on 4 d after treatment,then gradually decreased,and were lower than those at admission on 30 d,the difference was statistically significant(P<0.05).The levels of IL-1β,IL-6 and IL-18 at each time point 30 days in the mild injury patients were lower than those in the moderate injury patients,the difference was statistically significant(P<0.05).Conclusion The expression levels of serum IL-1β,IL-6 and IL-18 may be changed with the severity degree of craniocerebral injury,which may serve as the indicator for the severity of craniocerebral injury.关键词
颅脑损伤/炎性因子/白细胞介素-18/白细胞介素-1β/白细胞介素-6Key words
craniocerebral injury/inflammatory factors/IL-1β/IL-6/IL-18
