生物质化学工程2017，Vol.51Issue(2)：19-25,7.DOI:10.3969/j.issn.1673-5854.2017.02.004
乙酰丙酸还原胺化制备5-甲基-2-吡咯烷酮
Reductive Amination of Levulinic Acid to 5-Methyl-2-pyrrolidone
摘要
Abstract
The reductive amination of levulinic acid with ammonium formate as hydrogen and nitrogen donor to synthesize 5-methyl-2-pyrrolidone(5-MeP) in DMF solvent was developed and the mechanism of this process was proposed.The effects of various reaction conditions including temperature,reaction time,mass fraction and molar ratio of levulinic acid with ammonium formate and pH value on 5-methyl-2-pyrrolidone yield were investigated.Meanwhile,different solvents and levulinate derivatives were investigated in this system.The results showed that the properly increasing temperature,reaction time,the molar ratio and total mass fraction of levulinic acid and ammonium formate,and the pH value of system could improve the yield of 5-methyl-2-pyrrolidone.The polar aprotic solvents including formamide,DMA,DMSO and levulinate derivatives,such as methyl levulinate and α-angelica lactone,could also be respectively used as solvents and substrates in this system,too.关键词
吡咯烷酮/还原胺化/乙酰丙酸/生物质Key words
pyrrolidone/reductive amination/levulinic acid/biomass分类
化学化工引用本文复制引用
王彦钧,李铮,蒋叶涛,陈伟,曾宪海,孙勇,林鹿..乙酰丙酸还原胺化制备5-甲基-2-吡咯烷酮[J].生物质化学工程,2017,51(2):19-25,7.基金项目
福建省自然科学基金资助项目(2016J01077) （2016J01077）
厦门大学校长基金资助项目(20720160087) （20720160087）
