临床输血与检验2017，Vol.19Issue(1)：59-63,5.DOI:10.3969/j.issn.1671-2587.2017.01.017
血栓弹力图法和光学比浊法监测PCI术后氯吡格雷疗效的对比研究
Comparatively Study on the Thromboelastography and Light Transmission Aggregometry for Platelet Aggregation in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention under Antiplatelet Therapy
摘要
Abstract
Objective The dual antiplatelet drug for the treatment ofpercutaneous coronary intervention after operation of acute coronary syndrome patients,the by optical than Light Transmission Aggregometry (LTA) and method of thromboelastography (TEG) detection ofclopidogrel resistance (CPGR) consistency analysis,and compare the correlation with the levels of CYP2C19 enzyme activity.Methods A total of 425 patients with acute coronary syndrome treated with dual antiplatelet therapy and PCI in the Department of Cardiology during the period of January 2015 to November were collected.Consistency and correlation analysis of CPGR induced platelet aggregation rate (LTAADP) and ADP induced platelet inhibition rate (TEGADP) as well as the relationship between the two methods to detect CPGR and CYP2C19 gene expression level were done.Results The platelet aggregation rate measured by the LTA method was used to detect the CPGR as 12％.The platelet inhibition rate measured by the TEG method was used to detect the CPGR as 11.8％.There is a negative correlation between LTAADP and TEGADP (r=-0.351,P＜0.01);There was a certain degree of correlation between the activity ofCYP2C19 gene and the detection of CPGR by LTA method (r=0.239,P=0.00).No correlation between the degree of activity ofCYP2C19 gene and the detection of CPGR by TEG method (r=-0.088,P=0.70).And no significant difference between the two methods in the detection of CPGR was found.Conclusion TGE method and LTA method to monitor the efficacy of clopidogrel has well consistency,There was no significant difference between the two methods for the detection of CPGR with the degree of CYP2C19 gene activity.关键词
氯吡格雷抵抗/双联抗血小板/血栓弹力图/光学比浊法CYP2C19基因Key words
Clopidogrel resistance/Dual antiplatelet/Thromboelastography/Light transmission aggregometry CYP2C19分类
医药卫生引用本文复制引用
李广华,李阳华,范小斌,谢年谨,李正康,刘长钰,古俊兰..血栓弹力图法和光学比浊法监测PCI术后氯吡格雷疗效的对比研究[J].临床输血与检验,2017,19(1):59-63,5.基金项目
本课题受广东省医学科研基金(No.A2015442)资助 （No.A2015442）
