临床输血与检验2017，Vol.19Issue(2)：173-175,3.DOI:10.3969/j.issn.1671-2587.2017.02.023
江苏地区汉族人群HLA-E基因多态性分析
Polymorphic Analysis of HLA-E Gene in Han Population of Jiangsu Province
摘要
Abstract
Objective To investigate the genetic polymorphisms of HLA-E locus in Han population of Jiangsu region. Methods The genomic DNA extracted from 217 unrelated healthy blood donors were amplified by using HLA-E specific PCR primers.Results Two alleles including HLA-E*01:01 and HLA-E*01:03 were identified,the frequencies were 41.47% and58.53%,respectively.The frequencies of the three HLA-E genotypes(HLA-E*01:01/01:01,01:01/01:03 and 01:03/01:03)were14.74%,53.46% and31.80%,respectively,and they were in accordance with Hardy-Weinberg Equilibrium. Conclusion The polymorphism of HLA-E in the Han population of Jiangsu province was highly conserved,suggesting a role of HLA-E in disease association and clinical transplantation.关键词
人类白细胞抗原/HLA-E位点基因多态性Key words
Human/leukocyte/antigens/HLA-E/locus/Genetic/polymorphisms分类
医药卫生引用本文复制引用
林红,邵雷..江苏地区汉族人群HLA-E基因多态性分析[J].临床输血与检验,2017,19(2):173-175,3.基金项目
本课题受江苏省"六大人才高峰"项目(No.WSN-2014-002)资助 （No.WSN-2014-002）
