临床与实验病理学杂志2016，Vol.32Issue(12)：1348-1352,5.DOI:10.13315/j.cnki.cjcep.2016.12.007
少突胶质细胞瘤中FABP5的表达及其临床意义
Expression of FABP5 and its clinic pathological significance in oligodendroglioma
摘要
Abstract
Purpose To investigate the expression of FABP5 in oligodendroglioma and its clinic pathological significance.Methods Immunostaining of FABP5 and Ki-67 were performed in 87 oligodendrogliomas and 23 paracancerous brain tissues.The relationships between FABP5 expression and Ki-67 expression or clinic pathological parameters were statistically analyzed.Patients were followed up after operation.Results (1) The expression of FABP5 was significantly higher in oligodendroglioma [63.2％ (55/87)] than that in normal control [34.8％ (8/23)].(2)The expression of FABP5 was positively correlated with the histological grade (P =0.018,rs =0.254) and the Ki-67 expression (P =0.003,rs =0.318) in oligodendroglioma.(3) Univariate analysis showed that the expression of FABP5 protein,Ki-67 protein,age and chemotherapy were significant prognostic factors for oligodendroglioma patients.Conclusion FABP5 may play an important role in the pathogenesis and progression of oligodendroglioma,and could be used as a novel biological indicator of disease progress as well as prognosis for oligodendroglioma patients.关键词
脑肿瘤/少突胶质细胞瘤/脂肪酸结合蛋白5/Ki-67/预后/免疫组织化学Key words
brain neoplasms/oligodendroglioma/FABP5/Ki-67/prognosis/immunohistochemistry分类
医药卫生引用本文复制引用
高婉婉,赵霞,孟刚,蔡莉..少突胶质细胞瘤中FABP5的表达及其临床意义[J].临床与实验病理学杂志,2016,32(12):1348-1352,5.基金项目
国家自然科学基金(81201052) （81201052）
