临床与实验病理学杂志2016，Vol.32Issue(12)：1365-1367,3.DOI:10.13315/j.cnki.cjcep.2016.12.011
前列腺癌组织中miR-21的表达及临床意义
Expression of miR-21 in prostate cancer and its clinical significance
摘要
Abstract
Purpose To investigate the expression and clinical significance of microRNA-21 (miR-21) in patients with prostate cancer (PCa).Methods The human tissue specimens were paraffin-embedded blocks which were collected from the Department of Pathology.miR-21 was detected by in situ hybridization (ISH) in 90 cases of PCa and 69 cases of benign prostatic hyperplasia (BPH).Results The ISH data showed that the positive rate of miR-21 in PCa (71.1％) was significantly higher than that in BPH (24.6％) (P ＜ 0.05),the expression of miR-21 correlated with the Gleason grade (P ＜ 0.05),and no relationship was observed with other clinicpathological features (P ＞ 0.05).Conclusion The miR-21 plays an important role in the pathogenesis of PCa,which can be a new diagnostic target for PCa.关键词
前列腺肿瘤/良性前列腺增生/miR-21/原位分子杂交Key words
prostate neoplasm/benign prostatic hyperplasia/miR-21/in situ hybridization分类
医药卫生引用本文复制引用
张聪,曹立宇,尹玉,陈顺华,李玉洁..前列腺癌组织中miR-21的表达及临床意义[J].临床与实验病理学杂志,2016,32(12):1365-1367,3.基金项目
安徽省自然科学基金(KJ2013A150) （KJ2013A150）
