临床与实验病理学杂志2016，Vol.32Issue(12)：1368-1370,3.DOI:10.13315/j.cnki.cjcep.2016.12.012
分化型甲状腺癌中BRAF V600E突变分析
Analysis of BRAF V600E mutation in bilateral well-differentiated thyroid carcinoma
摘要
Abstract
Purpose To investigate the correlation between BRAF V600E mutation and clinicopathologic parameters in bilateral welldifferentiated thyroid carcinoma.Method Collected 80 patients with papillary thyoid carcinoma (PTC) (67 patients with classical type,8 patients with follicular variant,3 patients with oncocytic variant,2 patients with tall cell variant),5 patients with follicular carcinoma and 30 normal tissues near the tumor,BRAF V600E mutation was detected via polymerase chain reaction.Result The presence of BRAF V600E mutation was found in 52 patients with PTC (65.0％),the mutation was not in the 5 patients with ollicular carcinoma as well as in the 30 normal tissues near the tumor.The BRAF V600E mutation was positively correlated with age,capsule invasion,lymph node metastasis,tumor clinical stage.In the histological variant of PTC,the BRAF V600E mutation rate of classical type and tall cell variant is very high (70.1％,100.0％),but the BRAF V600E mutation rate of follicular variant is very low (33.3％).Conclusion The BRAF V600E mutation rates are different in different age groups.The BRAF V600E mutation was positively correlated with capsule invasion,lymph node metastasis,tumor clinical stage.The BRAF V600E mutation rate of classical type and tall cell variant is very higher than follicular variant.关键词
甲状腺肿瘤/分化型甲状腺癌/甲状腺乳头状癌/BRAF V600E突变/组织学亚型Key words
thyroid neoplasms/bilateral well-differentiated thyroid carcinoma/papillary thyoid carcinoma/BRAF V600E mutation/histological variant分类
医药卫生引用本文复制引用
罗雁,安宁,王兰,陆云,刘芳..分化型甲状腺癌中BRAF V600E突变分析[J].临床与实验病理学杂志,2016,32(12):1368-1370,3.基金项目
甘肃省卫生行业科研计划管理项目(GWGL2014-08) （GWGL2014-08）
