临床与实验病理学杂志2017，Vol.33Issue(1)：4-7,4.DOI:10.13315/j.cnki.cjcep.2017.01.002
宫腔粘连子宫内膜组织中ArhGAP29、E-cadherin的表达及意义
Expression and significance of ArhGAP29 and E-cadherin in intrauterine adhesions of endometrium
摘要
Abstract
Purpose To investigate the expression and significance of ArhGAP29 and E-cadherin in endometrial tissue of intrauterine adhesions (IUAs) and to explore their roles in the pathogenesis of IUAs.Methods The expression of ArhGAP29 and E-cadherin was detected by immunohistochemical PV 9000 two-step method.The correlation between ArhGAP29 and E-cadherin expression and clinical features was analyzed.Results (1) The immunoreactive score (IRS) of ArhGAP29 and E-cadherin in normal endometrial tissue were higher than those in IUAs endometrial tissue (P =0.017,P =0.004).(2) IRS of ArhGAP 29 and E-cadherin in moderate IUAs patients were higher than that in severe IUAs patients (P =0.020,P =0.026).In IUAs patients without amenorrhea,the IRS of ArhGAP29 and Ecadherin were higher (P =0.019,P =0.031) than that in IUAs patients with amenorrhea.(3) The decrease of ArhGAP29 expression had a significantly parallel relationship with the negative expression of E-cadherin (r =0.725,P ＜ 0.001).Conclusion The expression of ArhGAP29 and E-cadherin decreases in endometrial tissue of IUAs patients,which is related with degree of IUAs severity.ArhGAP29 and E-cadherin may participate in the IUAs formation.关键词
宫腔粘连/ArhGAP29/E-cadherin/上皮-间质转化/免疫组织化学Key words
intrauterine adhesions/ArhGAP29/E-cadherin/epithelial-mesenchymal transition/immunohistochemistry分类
医药卫生引用本文复制引用
徐倩,段华,汪沙,甘露,付凤仙,汤一群..宫腔粘连子宫内膜组织中ArhGAP29、E-cadherin的表达及意义[J].临床与实验病理学杂志,2017,33(1):4-7,4.基金项目
国家科技支撑计划(2014BAI05B03)、首都卫生发展科研专项经费资助(2014-1-2112)、北京市医院管理局临床医学发展专项经费资助(ZYLX201406) （2014BAI05B03）
