临床与实验病理学杂志2017，Vol.33Issue(1)：12-17,6.DOI:10.13315/j.cnki.cjcep.2017.01.004
健康体检人群肿瘤标志物的异常状态:分子水平肿瘤早期筛查的临床意义
Abnormal status of tumor markers detected among healthy physical examinees: clinical significance of early tumor screening at molecular level
摘要
Abstract
Purpose The aim of this study is to define "molecular sub-healthy" status among individuals attending routine physical examination.Methods This study examined 8 blood tumor markers among 5 825 healthy individuals.Results (1) Differences in levels of tumor markers were observed between males and females.(2) Elevated CA72-4 levels were seen in 16.05％ of individuals in both sexes.(3) More males had elevated levels of CEA and CYFRA21-1.Among the individuals with elevated levels of tumor markers,most were clustered in the prime age group of 41 to 50 years.Conclusion This is the first large-sample survey in healthy Han population in Xinjiang,which found elevated levels of all 8 markers tested with varying rates.Accordingly,this study proposes for the first time a concept of "molecular sub-healthy" status and a strategy of "early tumor screening at molecular level".The "molecular sub-healthy" status may be an early warning sign for potential cancers,which should draw attention by preventive public health policies.关键词
肿瘤标志物/分子水平亚健康/分子水平肿瘤筛查/健康体检/公共卫生政策Key words
tumor markers/molecular sub-healthy status/early tumor screening at molecular level/physical examination/preventive public health policy分类
医药卫生引用本文复制引用
马玉,马雅静,李旭哲,陈江,阴慧慧,张文杰..健康体检人群肿瘤标志物的异常状态:分子水平肿瘤早期筛查的临床意义[J].临床与实验病理学杂志,2017,33(1):12-17,6.基金项目
国家科技部科技支撑计划(2009BAI82B02) （2009BAI82B02）
